| 苏红艳 刘雅静 李亚醒 陈淑艳 朱晓华.氟比洛芬酯对食管癌患者围术期外周血淋巴细胞亚群的影响[J].现代生物医学进展英文版,2017,17(2):298-300. |
| 氟比洛芬酯对食管癌患者围术期外周血淋巴细胞亚群的影响 |
| Effect of Flurbiprofen Axetil on Patients with Esophageal CancerPerioperative Peripheral Blood Lymphocyte Subsets |
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| DOI： |
| 中文关键词: 氟比洛芬酯 食管癌 淋巴细胞亚群 |
| 英文关键词: Flurbiprofen axetil Esophageal cancer Lymphocyte subsets |
| 基金项目: |
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| 中文摘要: |
| 目的：探究氟比洛芬酯对食管癌患者围术期外周血淋巴细胞亚群的影响。方法：选择2014 年6 月~2016 年8 月期间在我院
择期行食管癌根治术患者72例为研究对象，采用随机数字法将其分为氟比洛芬酯组（39 例）和对照组（33 例），患者均给予常规
麻醉处理，对照组患者泵入5 mg托烷司琼与20 滋g/kg 芬太尼；氟比洛芬酯组患者给予氟比洛芬酯2 mg/kg。评价术后12 h、24 h
和48 h患者疼痛情况(VAS 评分)，并于术前1 h、术后24 h、术后72 h 检测患者血清T 细胞中CD3+、CD4+、CD8+及CD56+比例。
结果：两组患者术后不同时刻VAS 评分比较，差异均无统计学意义（P>0.05）；术后24 h两组患者CD3+、CD4+、CD4+/CD8+均显著
降低（P<0.05），术后72 h两组患者CD3+、CD4+、CD4+/CD8+水平均升高，且氟比洛芬酯组患者恢复到术后1 h水平，而对照组患者
均仍低于术后1 h，且术后72 h氟比洛芬酯组CD3+、CD4+、CD4+/CD8+均高于对照组，差异均有统计学意义（P<0.05），而CD8+与
CD56+比例在两组各个时点均没有变化（P>0.05）；两组患者均未发生严重不良反应。结论：食管癌患者在手术过程中均出现免疫
抑制，氟比洛芬酯麻醉效果较好，且对机体免疫功能具有保护作用，促进手术患者免疫功能的恢复，具有重要的临床价值。 |
| 英文摘要: |
| Objective:To explore the effect of flurbiprofen axetil on patients with esophageal cancer perioperative peripheral
blood lymphocyte subsets.Methods:72 cases of the radical operation of esophageal cancer in our hospital were selected as study subjects
from June 2014 to August 2016; They were randomly divided into flurbiprofen group(39 cases)and control group(33 cases), which were
given anesthesia treatment; The control group of patients with infusion of 5mg tropisetron and fentanyl 20 g/kg; flurbiprofen group were
given flurbiprofen 2 mg/kg. To evaluation of postoperative pain in patients with 12 h, 24 h, and 48 h, and to detect the proportion of
CD3+, CD4+, CD8+ and CD56+ in serum lymphocytes of patients on Preoperative 1 h, 24 h after operation, and postoperative 72 h.Results:The VAS score of patients in both groups had no statistically difference at different times (P>0.05); The level of CD3+, CD4+,
CD4+/CD8+ in both groups had significantly reduced(P<0.05) on 24 h moments and the level of CD3+, CD4+, CD4+/CD8+was elevated on
72 h moments; And flurbiprofen group were restored to the level of 1 h after operation, while the control group were still lower than that
of moment; And the level of CD3+, CD4+ and CD4+/CD8+ in flurbiprofen group were higher than the control group on 72 h moments(P<0.
05); And the level of CD8+ and CD56+ in two groups at each point of time has no change(P>0.05); No serious adverse reactions occurred
in the two groups.Conclusion:Immune suppression occurs in patients with esophageal cancer during the operation; Flurbiprofe's
anesthesia effect is good, and it has protective effect on immune function of organism, and promote the recovery of immune function in
patients with surgery, which has important clinical value. |
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