| 王莉 孙云燕 袁军 朱冬梅 郑丽君.TLR9 介导的Myd88信号通路分子在稽留流产患者绒毛组织中的表达
及其临床意义[J].现代生物医学进展英文版,2017,17(2):252-255. |
| TLR9 介导的Myd88信号通路分子在稽留流产患者绒毛组织中的表达
及其临床意义 |
| Expression and Clinical Significance of TLR9 Mediated Myd88 SignalingPathway in the Patients with Missed Abortion |
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| DOI： |
| 中文关键词: 稽留流产 Toll 样受体 Myd88 信号通路 绒毛组织 炎症反应 |
| 英文关键词: Missed abortion Toll-like receptors Myd88 signaling pathways Villi Inflammation |
| 基金项目:上海市自然科学基金项目（12ZR1424300） |
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| 中文摘要: |
| 目的：研究TLR9 介导的Myd88 信号通路在稽留流产患者绒毛组织中的表达及其临床意义。方法：本研究收集了稽留流产
患者及正常分娩者的绒毛组织，采用Real-time-PCR 及Western-blot方法检测了TLR9 介导Myd88 信号通路中TLR9、Myd88、
TNF-a、NF-kB、IRF1 mRNA 和蛋白表达。结果：与正常对照组相比较，TLR9、Myd88、TNF-a、NF-资B、IRF1 mRNA 和蛋白在稽留流
产组患者绒毛组织中相对表达水平显著升高，差异有统计学意义(P<0.05)。结论：稽留流产的发生与TLR9/Myd88 信号通路有关。 |
| 英文摘要: |
| Objective:To study the expression and clinical significance.of TLR9 mediated Myd88 signaling pathway in patients
with missed abortion.Methods:The villi tissue of missed abortion patients and normal delivery were collected. Real- time PCR and
Western blot method were used to detect the mRNA and protein expression of TLR9, Myd88, TNF-a, NF-kB, IRF1.Results:Compared
with normal control group, the mRNA and protein expression of TLR9, Myd88, TNF-a, NF-kB, IRF1were significantly raised in the
abortion group (P<0.05).Conclusion:TLR9/MyD88 signaling pathway might be involved in the pathogenesis of missed abortion. |
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