| 张进 张建军 张苗 吴锋 韦丽 王晶.磷酸西格列汀联合短期胰岛素强化治疗对初发2 型糖尿病患者血清25-
羟维生素D及胱抑素C 水平的影响[J].现代生物医学进展英文版,2016,16(33):6556-6559. |
| 磷酸西格列汀联合短期胰岛素强化治疗对初发2 型糖尿病患者血清25-
羟维生素D及胱抑素C 水平的影响 |
| Effect of Sitagliptin Phosphate combined with Short-termIntensive InsulinTreatment on the Serum25- hydroxyvitamin D and Cystatin C Levels ofPatients with Newly Diagnosed Type 2 Diabetes Mellitus |
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| DOI： |
| 中文关键词: 磷酸西格列汀 胰岛素 强化治疗 初发2 型糖尿病 |
| 英文关键词: Sitagliptin phosphate Insulin Intensive therapy Newly diagnosed type 2 diabetes mellitus |
| 基金项目:陕西省自然科学基金项目(1308085QH197) |
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| 中文摘要: |
| 目的：探讨磷酸西格列汀联合短期胰岛素强化治疗对初发2 型糖尿病患者血清25-羟维生素D及胱抑素C水平的影响。方
法：选择我院收治的初发2 型糖尿病患者70 例，根据电脑生成的随机数字表将所有患者随机分为实验组与对照组，每组35 例。
对照组患者给予磷酸西格列汀进行治疗，实验组患者在对照组的基础上联合短期的胰岛素强化治疗。比较治疗前后两组患者者
血清25- 羟维生素D(25(OH)D)、胰岛素抵抗指数(HOMA-IR)、胱抑素C(Cys C)、转化生长因子-beta1(TGF-beta1)、空腹血糖(FBG)及餐
后2h 血糖(2h BG)水平的变化。结果：与治疗前相比，两组患者治疗后的血清25(OH)D 水平均升高，HOMA-IR、Cys C、TGF-茁1、
FBG 及2h BG 水平均降低(P＜0.05)；与对照组相比，实验组患者血清25(OH)D 水平较高，HOMA-IR、Cys C、TGF-beta1、FBG 及2h
BG水平较低(P＜0.05)。结论：磷酸西格列汀联合短期胰岛素强化治疗能够有效改善初发2 型糖尿病患者的胰岛素抵抗、肾功能，
并降低血糖。 |
| 英文摘要: |
| Objective:To investigate the effect of sitagliptin phosphate combined with short-term intensive insulin treatment on
the serum 25- hydroxyvitamin D and cystatin c levels of patients with newly diagnosed type 2 diabetes mellitus.Methods:70 patients
with newly diagnosed type 2 diabetes mellitus fromour hospital were selected and randomly divided into the control group and the experimental
group with 35 cases in each group. The control group was treated by sitagliptin phosphate alone, while the experimental group
was treated on the basis of control group with short term intensive insulin therapy. The serum 25-Dihydroxy vitamin D (25(OH)D),
Homeostasis model assessment (HOMA-IR), cystatin C (Cys C), transforming growth factor-beta1 (TGF-beta1), fasting blood-glucose (FBG)
and 2-hour Blood Glucose (2h BG) levels were compared between two groups before and after treatment.Results:Compared with before
treatment, the serum 25 (OH)D level was significantly higher in both groups after treatment (P＜0.05), the HOMA-IR, Cys C, TGF-beta1,
FBG and 2h BG levels were obviously lower (P＜0.05). Compared with the control group, the serum 25 (OH)D level was significantly
higher in the experimental group (P＜0.05), the HOMA-IR, Cys C, TGF-茁1, FBG and 2h BG levels were lower (P＜0.05).Conclusion:Sitagliptin phosphate combined with short-term intensive insulin treatment could effectively improve the insulin resistance, renal function
and reduce the blood glucose in patients with newly diagnosed type 2 diabetes. |
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