| 沈珂珂 马豪莉 任丽君 高红红 张燕.2 型糖尿病患者血浆成纤维细胞生长因子-21 水平的变化及意义[J].现代生物医学进展英文版,2016,16(33):6526-6528. |
| 2 型糖尿病患者血浆成纤维细胞生长因子-21 水平的变化及意义 |
| Change of Plasma Fibroblast Growth Factor-21 Level of Type 2 DiabeticPatients and its Clinical Significance |
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| DOI： |
| 中文关键词: 成纤维细胞生长因子/血液 糖尿病 2 型 糖尿病血管病变 |
| 英文关键词: Fibroblast Growth Factors/BL Diabetes Mellitus Type 2 Diabetic Angiopathies |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨2 型糖尿病(type 2 diabetes mellitus,T2DM)患者血浆成纤维细胞生长因子-21(fibroblast growth factor 21,FGF-21)
水平变化以及观察短期胰岛素强化治疗对FGF-21水平的影响。方法：选择我院2013年1月至2015年1 月收治的T2DM 患者64
例，其中初诊T2DM 患者32 例(T2DM组)，T2DM合并大血管病变患者32 例(合并大血管病变组)，并选择同期体检健康者30 例
(对照组)。采用酶联免疫法测定三组血浆FGF-21 水平以及胰岛素强化治疗前后的变化，分析血浆FGF-21 水平与体质量指数
(BMI)、腰臀比(WHR)、血脂、血糖、空腹血浆胰岛素(FINS)和糖化血红蛋白(HbA1C)等水平的关系。结果：T2DM 组及T2DM 合并
大血管病变组患者空腹血浆FGF-21 水平明显高于对照组(P<0.05)，T2DM 合并大血管病变组患者空腹血浆FGF-21 水平明显高
于T2DM组和对照组(P<0.05)。空腹血浆FGF-21 水平与T2DM 患者FPG、HbA1C 水平呈明显正相关，WHR、舒张压、HbA1C是
影响血浆FGF-21水平的独立相关因素。经胰岛素强化治疗后，血浆FGF-21 水平较治疗前明显下降(P<0.05)。结论：T2DM患者血
浆FGF-21 水平明显升高，可能参与了T2DM 及其大血管病变的发生和发展，胰岛素强化治疗可明显降低T2DM 患者血浆
FGF-21 水平，血浆FGF-21 可能作为T2DM病情和疗效评估的参考指标。 |
| 英文摘要: |
| Objective:To explore the change of plasma fibroblast growth factor 21 (FGF-21) in type 2 diabetes melli-tus(T2DM)
patients with macroangiopathy, and to observe the effect of short-term intensive insulin therapy on FGF-21 level.Methods:Enzyme
linked immunosorbent assay (ELISA) was used to detect plasma FGF-21 in 30 healthy controls (control group), 32 patients with newly
diagnosed T2DM(T2DMgroup) and 32 T2DMpatients with macroangiopathy (diabetic macroangiopathy group). The change of FGF-21
before and after intensive insulin therapy was observed. The relationship of plasma FGF-21 with body mass index (BMI), waist/hip ratio
(WHR), blood lipids, plasma glucose, fast-ing plasma insulin(FIN2) and glycosylated hemoglobin(HbA1C) was analyzed.Results:Plasma
level of FGF-21 in T2DM patients with macroangiopathy was increased obviously. The fasting plasma FGF-21 level was positively
correlated with FPG and HbA1C. The WHR, diastolic pressure and HbA1C were the independent factors influencing plasma level of
FGF-21. Compared with before treatment, plasma level of FGF-21 after intensive insulin therapy was reduced obviously.Conclusion:Plasma FGF-21 may participate in the pathogenesis and development of T 2DM and diabetic macroangiopathy. Short-term intensive insulin
therapy can obviously decrease plasma FGF-21 level in T2DMpatients. |
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