| 赵直光 唐中权 曹赛霞 杨书彦 曹艳玲 王梅.血清胱抑素C 与乙型肝炎性肝硬化肝功能损害程度的相关性分析[J].现代生物医学进展英文版,2016,16(33):6519-6521. |
| 血清胱抑素C 与乙型肝炎性肝硬化肝功能损害程度的相关性分析 |
| Correlation Analysis of Serum Cystatin Level and Liver Function Damage inPatients with Posthepatitic B Cirrhosis |
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| DOI： |
| 中文关键词: 慢性乙型肝炎 肝硬化 Child-Pugh 评分 血清胱抑素 |
| 英文关键词: Chronic hepatitis b Liver Cirrhosis Child - Pugh score Serumcystatin |
| 基金项目:内蒙古自然科学基金项目（2011MS1117） |
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| 中文摘要: |
| 目的：探讨血清胱抑素C(CysC)与乙型肝炎性肝硬化患者肝功能损伤程度的相关性分析。方法：将98 例乙型肝炎性肝硬化
患者按照肝功能分级的Child-Pugh 评分将分为A 组(Child A级，n=45 例)、B 组(Child B级，n=33 例)、C 组(Child C级，n=20 例)，
同期选取本院门诊正常健康体检者为对照组，检测所有受试者的血清CysC 水平，比较各种之间相关指标的差异。结果：A组、B
组、C组、对照组丙氨酸氨基转移酶(ALT)、天门冬氨酸转移酶(AST)、血清白蛋白(ALB)、血清CysC 及血清CysC 阳性率均有统计
学差异(P＜0.05)，C 组血清CysC、血清CysC 阳性率高于对照组(P＜0.05)、A 组、B 组，而B 组高于对照组、A 组(P＜0.05)；血清
CysC 阳性组与阴性组中含有Child A级、Child B级、Child C级患者的构成比具有统计学意义(P＜0.05)，CysC 阳性组中的Child
C 级患者比例高于阴性组(P＜0.05)；血清CysC与Child-Pugh 评分呈正相关(P＜0.05)；Child-Pugh 评分、ALT、AST 与患者血清
CysC 阳性呈正相关(P＜0.05)；而ALB 则与其呈负相关(P＜0.05)；结论：乙型肝炎性肝硬化患者血清CysC 水平与肝功能损伤程度
呈一定相关性，早期检测血清CysC 水平对于评估乙型肝炎性肝硬化患者的肝功能损害具有一定的临床意义。 |
| 英文摘要: |
| Objective:To investigate the correlation of serum cystatin (CysC) level and liver function damage in patients with posthepatitic
B cirrhosis.Methods:98 patients with hepatitisB cirrhosis liver function according to the classification of the Child-Pugh score
will be divided into group A(Child class A, n=45) and group B(Child class B, n=33), group C(Child class C, n=20). At the same time, the
healthy peoples having normal physical examination in our hospital clinic were selected as control. Detect serum CysC level of all subjects,
and compare the differences in various relevant indicators between groups.Results:The levels of alanine aminotransferase (ALT),
aspartate transaminase (AST) (propagated), serum albumin, serum CysC and positive rate of serum CysC had statistical difference between
group A, B, C and the control group (P<0.05). The serumCysC level and its positive rate of group C were the highest among the
groups (P<0.05), and those of group B were higher than those of the control group and groupA (P<0.05). In the serum CysC positive
group, the constituent ratio of patients with Child class A, B and C was statistically different with that in the serum CysC negative group
(P<0.05). The percentage of patients with Child class C was higher in CysC positive group than in negative group (P<0.05). Serum CysC
levels were positively correlated with the Child-Pugh scores (P<0.05). The Child-Pugh score, levels of ALT and AST were positively correlated
with the positive serumCysC (P<0.05), while ALB level was negatively correlated with it (P<0.05).Conclusion:The serumCysC
level of hepatitis B cirrhosis patients had a correlation with the liver function damage degree. Early detection of serum CysC level has a
certain clinical significance in evaluating liver function damage of hepatitis B patients with liver cirrhosis. |
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