| Objective:To investigate the effect of metformin combined with pioglitazone on the oxidative stress and insulin resistance
in patients with type 2 diabetes mellitus.Methods:80 patients with type 2 diabetes mellitus were selected and randomly divided into
experiment group and control group with 40 cases in each group. After admission, the patients in the two groups were given corresponding
treatment measures, while the control group was treated with metformin 250 mg/time, twice daily, and the patients in the experimental
group were given sitagliptin 100 mg / time, once a day on the basis of the control group, respectively for 8 weeks. After the end of the
treatment, the serum level of malondialdehyde (MDA), 8 ISO prostaglandin F2 alpha (8-iso-pgf2alpha), fasting blood glucose (FBG), fasting
insulin (FINS), insulin resistance index (HOMA-IR) and the clinical efficacy were detected and compared.Results:Compared with before
treatment, the MDA, 8-iso-pgf2alpha, FBG, fins and HOMA-IR levels were decreased after treatment in the two groups of patients(P<0.
05); compared with the control group, the MDA, 8-iso-pgf2alpha, FBG, fins and HOMA-IR levels were lower (P<0.05), the total effective
rate was higher (P<0.05) in the experimental group.Conclusion:The combination of metformin and pioglitazone has good clinical effect
in treatment of type 2 diabetes mellitus, it can reduce the blood glucose and MDA and 8-iso-PGF2 level, alleviate oxidative stress and insulin
resistance. |
