| 郭思聪 刘兴利 贾晨红 张新忠 万继业 李晓东.NT-proBNP与急性冠脉综合征患者冠脉病变程度及预后的关系[J].现代生物医学进展英文版,2016,16(33):6463-6466. |
| NT-proBNP与急性冠脉综合征患者冠脉病变程度及预后的关系 |
| Correlation between NT-proBNP and Coronary Artery Disease and Prognosisin Patients with Acute Coronary Syndrome |
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| DOI： |
| 中文关键词: NT-proBNP 急性冠脉综合征 冠脉病变 预后 相关性 |
| 英文关键词: N-terminal pro brain natriuretic peptide Acute coronary syndrome Coronary artery disease Prognosis Correlation |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨N末端脑钠肽原（NT-proBNP）与急性冠脉综合征（ACS）患者冠脉病变程度及预后的关系。方法：选择2012 年1
月至2015 年6 月我院收治的ACS 患者400 例为研究对象，根据病情症状的不同将患者分为不稳定心绞痛（UA）组和急性心肌梗
死（AMI）组，各200 例，另选同期200 例非ACS患者作为对照组，比较各组患者的NT-proBNP 水平及ACS 患者的心功能情况，
并比较ACS 患者的冠脉造影结果，通过Syntax 评分系统评价冠脉病变，随访6-12 个月，对比各组患者的主要心血管不良事件
(MACE)发生率，通过上述比较及分析，研究ACS 患者NT-proBNP与冠脉病变程度及预后的关系。结果：AMI组及UA组患者的
NT-proBNP 水平明显高于对照组，且AMI组患者的NT-proBNP 水平明显高于UA组，差异有统计学意义(P<0.05)；AMI 组患者
的冠脉病变Syntax 积分高于UA 组，差异有统计学意义(P<0.05)；冠脉病变Syntax 积分≥ 33 分的ACS患者的NT-proBNP 水平
高于Syntax 积分0-22 分的患者，差异有统计学意义（P＜0.05）；同时双支病变和三支病变患者的Syntax 积分及NT-proBNP 水平
高于单支病变患者，差异有统计学意义（P＜0.05）；随访6-12 个月发生MACE 患者的NT-proBNP 水平明显高于未发生MACE
者，差异有统计学意义（P＜0.05）。Pearson 相关性分析显示，患者的冠脉病变程度与NT-proBNP 及Syntas 积分均呈正相关（r=0.
667，0.842；P<0.05）。患者随访6-12 个月MACE 发生率与NT-proBNP及Syntas 积分也呈正相关（r=0.708，0.821；P<0.05）。结论：
ACS 患者的冠脉病变程度及预后与其NT-proBNP水平具有较好的相关性，值得临床关注。 |
| 英文摘要: |
| Objective:To study the correlation between N-terminal pro brain natriuretic peptide (NT-proBNP)and acute coronary
syndrome (ACS)and prognosis in patients with acute coronary syndrome.Methods:Selected 400 cases of patients with ACS who treated
in our hospital from January 2012 to June 2015 as the objects,and were divided into unstable angina pectoris (UAP)group and acute myocardial
infarction(AMI)group according to the different symptoms of the disease, with 200 patients in each group, and selected 200 cases
of normal non ACS patients as the control group over the same period, compared the NT-proBNP level and heart function of patients in
each group, compared the results of coronary angiography in patients with ACS, and evaluation of coronary artery disease by Syntax
scoring system, followed-up 6-12 months, compared the incidence rate of major cardiovascular adverse events (MACE)in each groups,
through the above comparison and analysis, explore the correlation between NT-proBNP and coronary lesion degree and prognosis in patients
with ACS.Results:The NT-proBNP levels of patients in AMI group and UA group were significantly higher than control group,
and the NT-proBNP level of patients in AMI group was higher than those in UA group, the differences were statistically significant(P<0.
05); The Syntax coronary lesion score in AMI group were higher than those in UA group, the NT-proBNP level of ACS patients with
Syntax coronary lesion score≥ 33 were higher than the patients with Syntax score 0-22, the difference was statistically significant(P<0.
05); At the same time, the Syntax scores and NT-proBNP levels of patients with double branch lesions and three lesions were higher than
that with single lesions, the differences were statistically significant(P<0.05); The NT-proBNP levels of patients with MACE were significantly
higher than those without MACE after followed-up of 6-12 months, the differences was statistically significant (P<0.05). Pearson
correlation analysis showed that, the degree of coronary artery disease was positively correlated with NT-proBNP and Syntas scores(r=0.
667, 0.842; P<0.05), the incidence of patients who followed-up for 6-12 months with MACE was positively correlated with NT-proBNP and Syntas scores (r=0.708, 0.821; P<0.05).Conclusion:The degree of coronary artery disease and prognosis of ACS patients with
NT-proBNP and Syntas points have good correlation, which is worthy of clinical attention. |
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