| Objective:To investigate the clinical characteristics, diagnosis and treatment of central nervous system (CNS) nocardiosis.Methods:1 patients in Affiliated Hospital of Qingdao University who were sufferred from brain Nocardia abscess were reported,
and searched the literatures with a total of 31 cases, the above 32 patients were analyzed retrospectively.Results:Among the 32 cases of
cerebral Nocardia infection patients, 22 cases had underlying diseases, 18 cases with glucocorticoids or immunosuppressive treatment
history. The main clinical manifestation of 15 patients was headache, fever, vomit, slurred speech, Unconsciousness, Physical dysfunction.
7 cases were treated with single trimethoprim/sulphamethoxazole, the other patients were given combination treatment, including
trimethoprim/sulphamethoxazole, quinolones, aminoglycoside, beta lactam, Linezolid. 9 patients died, the other 23 cases were improved
or cured.Conclusion:Immunocompromised is a recognized risk factor for the growth of nocardial brain abscesses. Nocardia positive
culture is the only way to diagnose the disease, sulfony amine is the first choice of treatment, if necessary, combined use of other drugs.
Poor outcome is mostly found in immunocompromised hosts. |
