| 姚大勇 史策 夏舜尧 兰文家 刘天伯 修有成.术前外周血中性粒细胞/淋巴细胞比值与肾癌临床病理特点及预后关系的研究[J].现代生物医学进展英文版,2016,16(32):6379-6383. |
| 术前外周血中性粒细胞/淋巴细胞比值与肾癌临床病理特点及预后关系的研究 |
| The Relationship Between Preoperative Neutrophil to Lymphocyte Ratio andClinicopathological Features and Prognosis of Patients with Renal Cancer |
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| DOI： |
| 中文关键词: 肾癌 中性粒细胞/淋巴细胞计数 预后 |
| 英文关键词: Renal cancer Neutrophil to lymphocyte ratio Prognosis |
| 基金项目:国家自然科学基金项目（81502225）；国家博士后基金项目（2015M581480） |
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| 中文摘要: |
| 目的：分析术前外周血中性粒细胞/ 淋巴细胞比值(NLR)与肾癌临床病理特征及预后的关系。方法：回顾性分析2007 年1
月～2011年12月在哈尔滨医科大学附属第一医院泌尿外科接受根治性手术且病理证实为非转移肾癌患者的临床病例及随访资
料。根据ROC 曲线确定NLR 最佳截点，并以此截点将患者分为高NLR 组和低NLR 组。分析两组间临床病理特征的差异。应用
Kaplan-Meier 法、Log-rank 法进行单因素生存分析，应用Cox 风险回归模型进行多因素生存分析。结果：460 例患者中，男性306
例，女性154 例，中位年龄56岁。NLR 平均值为2.34± 1.77，中位值为2.45。根据ROC曲线分析，当NLR 为2.5 时，曲线下面积
(AUC=0.628，p<0.001)最大。以此截点将患者分为高NLR(≥ 2.5)组154 例，低NLR(<2.5)组306 例。两组间年龄、Fuhrman 分期、T
分期上差异具有统计学意义(p<0.05)。单因素生存分析显示Fuhrman、T 分期、NLR 值是肾癌预后因素，Cox 多因素回归分析显示
T 分期、NLR 值是肾癌的独立预后因素。结论：术前外周血中性粒细胞/ 淋巴细胞比值(NLR)是肾癌患者预后不良的独立危险因
素。 |
| 英文摘要: |
| Objective:To evaluate the relationship between preoperative peripheral blood neutrophil to lymphocyte ratio (NLR)
and clinicopathologic variables and prognosis of patients with renal cancer.Methods:The clinical pathological and followed-up data of
460 cases of patients with pathologically confirmed renal cancer and underwent radical nephrectomy were retrospectively analyzed.
According to ROC curves, the optimal cut-off value of NLR was obtained and patients were divided into high NLR group and low NLR
group. And the clinicopathologic factors within two groups were analyzed. The survival of patients were analyzed by Kaplan-Meier,
Log-rank and Cox proportional hazards regresion analysis.Results:Of all 460 patients, there were 306 male and 154 female with a
median age of 56 years old. The mean NLR value was 2.34± 1.77, and median value was 2.45. According to ROC analysis, the best
cutoff value was 2.5 (AUC=0.628, P<0.001) and patients were divided into high NLR group (154 patients), and low NLR group (306
patients). The differences of age, Fuhrman classification, T classification between two groups was statistically significant (p<0.05).
Univariate analysis showed that Fuhrman classification, T classification and NLR value were prognostic factors. Multivariate analysis
also showed that T classification and NLR value were independent prognostic factors.Conclusion:Preoperative peripheral blood
neutrophil to lymphocyte ratio (NLR) was an independent poor prognostic factor of patients with renal cancer. |
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