| 杜赢 牛焕红 温慧 付小宁 曹林昌.甘利欣联合阿奇霉素治疗支原体肺炎伴肝功能损害患儿的效果
及对血清炎症因子、KL-6 及NF-κB 水平的影响[J].现代生物医学进展英文版,2016,16(32):6348-6352. |
| 甘利欣联合阿奇霉素治疗支原体肺炎伴肝功能损害患儿的效果
及对血清炎症因子、KL-6 及NF-κB 水平的影响 |
| Effect of DiammoniumGlycyrrhizinate combined with Azithromycin in theTreatment of Mycoplasma Pneumonia with Liver Function Damage andInfluence on Levels of SerumInflammation, KL-6 and NF-κB in Children |
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| DOI： |
| 中文关键词: 甘利欣 阿奇霉素 支原体肺炎 肝功能损害 血清炎症因子 KL-6 NF-κB |
| 英文关键词: Diammonium Glycyrrhizinate Azithromycin Mycoplasma pneumonia Liver function damage Inflammatory factor KL-6 NF-κB |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨甘利欣联合阿奇霉素治疗对支原体肺炎伴急性肝功能损害患儿血清炎症因子、Ⅱ型肺泡表面抗原-6（KL-6）及核
因子-κB（NF-κB）水平的影响。方法：选取86 例支原体肺炎伴急性肝功能损害患儿为受试对象，随机数字表法分成研究组和对照
组各43 例。对照组中途脱落1 例，共42例有效病例入组，予以常规对症治疗+ 阿奇霉素疗法；研究组中途脱落3 例，共40 例有
效病例入组，在对照组治疗基础上联合甘利欣静脉滴注疗法。观察对比两组受试患儿治疗前后血清炎症因子[白细胞介素-6
(IL-6)、白细胞介素-12(IL-12)及肿瘤坏死因子-α（TNF-α）]、血清KL-6、血清NF-κB、肝功能指标[血清丙氨酸氨基转移酶(ALT)、天
门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)]变化情况，记录其发热、咳嗽、肺部湿罗音等消失时间差异。结果：治疗4w后，两组患
儿IL-6[(44.5± 6.2)pg/mL vs (60.3± 6.6)pg/mL]、IL-12[(42.4± 6.2)pg/mL vs (52.1± 6.8)pg/mL]、TNF-α[(128.6± 44.8)ng/L vs (201.4±
51.8)ng/L] 等血清炎症因子检测结果、ALT [(46.8± 9.5)U/I vs (83.6± 9.8)U/I]、AST [(62.2± 10.1)U/I vs (84.8± 10.2)U/I]、TBIL[
(38.2± 8.5)umol/L vs (49.3± 9.0)umol/L]等肝功能指标检测结果及血清KL-6[(5.9± 0.6)pg/mL vs (6.5± 0.7)pg/mL]、NF-κB[(7.8±
0.4)pg/mL vs (8.1± 0.3)pg/mL]水平均较治疗前显著降低，且研究组小于对照组，差异有统计学意义（P＜0.05）。研究组患儿治疗后
发热、咳嗽、肺部湿罗音等消失时间均显著短于对照组患儿，差异有统计学意义（P＜0.05)。结论：甘利欣联合阿奇霉素疗法可在促
进支原体肺炎伴急性肝功能损害患儿病情转归、改善其血清炎症因子、调节肺功能、肝功能状态等方面发挥积极作用。 |
| 英文摘要: |
| Objective:To explore the effect of Diammonium Glycyrrhizinate combined with azithromycin in the treatment of
mycoplasma pneumonia with liver function damage and influence on levels of serum inflammation, KL-6 and NF-κB in children.Methods:Eighty-six cases of children with mycoplasma pneumonia complicated with acute liver function damage were selected as
subjects. According to the random number table method, they were divided into study group and control group, 43 cases in each. There
was 1 case lost to follow up in the control group and 42 cases enrolled. The control group was treated with routine symptomatic treatment
and azithromycin. There were 3 cases lost to follow up in study group and a total of 40 cases enrolled. On the basis of control group, the
study group was treated with intravenous infusion of Diammonium Glycyrrhizinate. The changes of serum inflammatory factors
[interleukin-6 (IL-6), interleukin-12 (IL-12), tumor necrosis factor alpha (TNF-α)], serum KL-6, serum NF-κB and liver function indexes
[serum alanine aminotransferase (ALT), aspartate amino transferase (AST), total bilirubin (TBIL)] in the two groups before and after
treatment were observed and compared. The differences in extinction time of fever, cough and lung wet rales, etc. were recorded.Results:After 4 weeks of treatment, the detection results of serum inflammatory factors such as IL-6 [(44.5± 6.2)pg/mL vs (60.3± 6.6)pg/mL],
IL-12 [(42.4± 6.2)pg/mL vs (52.1± 6.8)pg/mL] and TNF-α[(128.6± 44.8)ng/L vs (201.4± 51.8)ng/L], liver function indexes such as
ALT [(46.8± 9.5)U/I vs (83.6± 9.8)U/I], AST [(62.2± 10.1)U/I vs (84.8± 10.2)U/I] and TBIL [(38.2± 8.5)umol/L vs (49.3± 9.0)
umol/L], serum KL-6[(5.9± 0.6)pg/mL vs (6.5± 0.7)pg/mL] and NF-κB[(7.8± 0.4)pg/mL vs (8.1± 0.3)pg/mL] in the two groups were
significantly lower than those before treatment, and those in the study group were lower than the control group (P < 0.05). The extinction
time of fever, cough and lung wet rales, etc. in study group was significantly shorter than that in the control group (P < 0.05).Conclusion:DiammoniumGlycyrrhizinate combined with azithromycin can promote outcome of mycoplasma pneumonia with acute liver damage in children and improve the seruminflammatory factors, and it plays a positive role in regulating lung function and liver function. |
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