| 杨琴 吴海波 张艳琴 王宁 王文娟.基质金属蛋白酶-2 在子宫内膜异位症中的表达及应用价值[J].现代生物医学进展英文版,2016,16(32):6322-6325. |
| 基质金属蛋白酶-2 在子宫内膜异位症中的表达及应用价值 |
| Expression of MMP-2 in Endometriosis Tissues and Its Application Value |
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| DOI： |
| 中文关键词: CD44v6 MMP-2 子宫内膜异位症 在位内膜 异位内膜 |
| 英文关键词: CD44 splice variant 6 Matrix metalloproteinase-2 Endometriosis Eutopic endometria Ectopic endometrial |
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| 中文摘要: |
| 目的：探讨粘附分子CD44拼构变异体6（CD44v6）和基质金属蛋白酶-2（MMP-2）在子宫内膜异位症（EMs）组织中的表达及
相关性。方法：选取20 例异位内膜组织标本、20 例在位内膜组织标本及20 例正常子宫内膜标本，用病理常规免疫组织化学方法
检测MMP-2 和CD44v6 的表达，并分析其相关性。结果：CD44v6 在异位内膜组的表达明显高于在位内膜组和对照组，且对照组
明显高于在位内膜组，差异具有统计学意义（P<0.05）；CD44v6 在在位内膜组和对照组中分泌期的表达明显高于同组增生期，差
异具有统计学意义（P<0.05）。MMP-2 在异位内膜组和在位内膜组的表达明显高于对照组，差异具有统计学意义（P<0.01）；MMP-2
在各组增生期和分泌期表达不规律。异位内膜组中，CD44v6 和MMP-2 在Ⅲ-Ⅳ期的表达明显高于Ⅰ-Ⅱ期，差异具有统计学意义
（P<0.01）。Spearman 相关性分析结果显示：EMs组织中MMP-2 和CD44v6 之间呈现正相关性（r=0.724，P<0.05）；EMs不同分期组
织中MMP-2 和CD44v6 之间亦呈现正相关性（r=0.623，P<0.05）。结论：MMP-2 和CD44v6 在EMs 异位内膜中高表达，且有正协
同作用，二者可能与EMs 的发生发展有关。 |
| 英文摘要: |
| Objective:To investigate the expression of CD44 splice variant6 (CD44v6) and matrix metalloproteinase-2 (MMP-2)
in endometriosis tissues and analyze theirs correlation.Methods:20 cases of ectopic endometrial tissues, 20 cases of eutopic endometrial
tissues and 20 cases of normal endometrium were selected. The expression of CD44v6 and MMP-2 in these tissues were detected by
immunohistochemistry. The correlation between the expressions was analyzed.Results:The expression of CD44v6 in ectopic
endometrium group was significantly higher than that in eutopic endometrium and control group, and that in control group was
significantly higher than eutopic endometrium group, the differences were statistically significant (P<0.05). CD44v6 expression in
secretory stage of eutopic endometrium and control group was significantly higher than that in proliferative stage, and the differences
were statistically significant (P<0.05). MMP-2 expression in ectopic and eutopic endometriumgroups were significantly higher than that
in control group, and the differences were statistically significant (P<0.01). MMP-2 expression in secretory stage and proliferative stage
was not regular in all groups. In ectopic endometrium group, the expression of CD44v6 and MMP-2 in Ⅲ -Ⅳ stages were significantly
higher than that in I-II stages, and the differences were statistically significant (P<0.01). Spearman correlation analysis showed that the
CD44v6 and MMP-2 in EMS tissues showed positive correlation (r=0.724, P<0.05). CD44v6 and MMP-2 expression in EMS tissues in
different stages also revealed positive correlation (r=0.623, P<0.05).Conclusion:CD44v6 and MMP-2 are highly expressed in ectopic
endometriumof EMs and are positively correlated with each other, which may relate to the occurrence and development of EMs. |
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