| 吉宗珊 庄德舒 汝童 权威 高秀荣.糖尿病视网膜病变患者内皮祖细胞的数量变化分析[J].现代生物医学进展英文版,2016,16(32):6252-6255. |
| 糖尿病视网膜病变患者内皮祖细胞的数量变化分析 |
| Changs in the Number of Endothelial Progenitor Cells in Patienes withDiabetic Retinopathy |
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| DOI： |
| 中文关键词: 糖尿病视网膜病变 糖尿病血管并发症 内皮祖细胞（EPCs） 数量 |
| 英文关键词: Diabetic retinopathy Diabetic vascular complications Endothelial progenitor cells Number |
| 基金项目:国家自然科学基金项目（81072392）；哈尔滨市科技局青年科学研究基金项目(2002AFQQJ015) |
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| 中文摘要: |
| 目的：研究糖尿病视网膜病变患者内皮祖细胞（EPCs）的数量变化，从而探讨内皮祖细胞是否参与了糖尿病微血管病并发症
的发生发展。方法：选择与年龄、性别相匹配的患者，共124 例，其中健康对照组62 例，单纯糖尿病组31 例（DM组），糖尿病背景
期视网膜病变15 例（DM+NPDR组），糖尿病增殖期视网膜病变组16例（DM+PDR 组）。采用密度梯度离心法从人外周血分离出
单个核细胞，通过流式细胞仪检测内皮祖细胞数量。结果：与健康对照组相比，DM组、DM+NPDR组、DM+PDR 组的外周血EPCs
的数量明显减少（P<0.05）。DM+NPDR组与DM组相比，外周血EPCs数量无统计学差异（P＞0.05）。DM+PDR 组与DM组相比，
外周血EPCs 数量显著增加（P＜0.05）。结论：EPCs参与了糖尿病微血管并发症的发生发展，有望在临床治疗中成为潜在的治疗靶点。 |
| 英文摘要: |
| Objective:To study the number of endothelial progenitor cells (EPCs) frompatients with diabetic retinopathy , so as
to explore whether endothelial progenitor cells (EPCs) participate in the development of diabetic microangiopathy complication.Methods:Choose the patients of matching with age and sex, in total include 124 ases, with 62 cases in healthy control group, simple
diabetes group 31 cases (DMgroup), 15 cases with background diabetic retinopathy (DM+NPDP group), 16 cases with the proliferatiive
diabetic retinopath (DM + PDR). Using density gradient centrifugation, isolated from human peripheral blood mononuclear cells ，the
number of endothelial progenitor cells was detected through the flow cytometry.Results:Compared with healthy controls, the number of
peripheral blood was decreased significantly patients with the DMgroup, the DM+ NPDR group, and the DM + PDR group (P < 0.05).
DM + NPDR group compared with DM group, the number of peripheral blood EPCs no statistical difference (P > 0.05). DM + PDR
group compared with DMgroup, the number of peripheral blood EPCs increased significantly (P < 0.05).Conclusion:EPCs are involved
in the development of diabetic microvascular complications, is expected to become potential therapeutic targets in the clinical treatment. |
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