| 李自超 葛朝明△ 蔡宏斌 范祯祯 翟晓斌.耐药性结核性脑膜炎研究进展[J].现代生物医学进展英文版,2016,16(31):6192-6196. |
| 耐药性结核性脑膜炎研究进展 |
| Clinical Research Progress of Drug-resistance of Tuberculous Meningitis |
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| DOI： |
| 中文关键词: 耐药性 结核性脑膜炎 诊断 |
| 英文关键词: Drug-resistance Tuberculous meningitis Diagnosis |
| 基金项目:国家卫计委计划基金项目（NCT02397655） |
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| 中文摘要: |
| 结核性脑膜炎是由结核杆菌引起的中枢感染性疾病，是肺外结核病中最严重的一种，其多侵袭脑膜，有时可累及脑实质、脊
髓，有很高的致死率。结核病在发展中国家中的感染趋势尤为突出。我国为人口大国，抗结核治疗和预防的形势异常严峻。随着
抗结核药物的广泛使用，耐药性结核性脑膜炎患者数量增加，严重影响了结核性脑膜炎的预后。在耐药性结核性脑膜炎患者的治
疗中，早期诊断、经验性治疗、调整治疗方案对患者的预后尤为重要。本文对耐药性结核性脑膜炎的分布、临床诊断、基因检测、治
疗方案及预后进行系统性的总结。 |
| 英文摘要: |
| Tuberculous meningitis, one of the most serious cases of pulmonary tuberculosis, is a central infectious disease caused
by Mycobacterium tuberculosis. It has a high rate of death. Tuberculosis infection is particularly prominent in developing countries. As a
populous country, the situation of anti TB treatment and prevention is very serious. With the widespread use of anti TB drugs, the number
of patients with drug-resistant tuberculosis meningitis is increasing, seriously affect the prognosis of tuberculous meningitis. In the treatment
of patients with drug-resistant tuberculosis meningitis, early diagnosis, empirical treatment, adjust the treatment plan is particularly
important for the prognosis of patients. In this paper, the distribution, clinical diagnosis, gene detection, treatment and prognosis of drug
resistant tuberculosis meningitis are summarized systematically. |
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