| 薛娟 张媛媛 袁秀红 李丽 李红梅.促性腺激素释放激素激动剂与维生素E 对子宫内膜异位症不孕患者血清
TNF-alpha及IL-6水平的影响[J].现代生物医学进展英文版,2016,16(31):6155-6157. |
| 促性腺激素释放激素激动剂与维生素E 对子宫内膜异位症不孕患者血清
TNF-alpha及IL-6水平的影响 |
| Effect of Gonadotropin Releasing Hormone Agonist Combined with VitaminE on the SerumLevels of TNF-alpha and IL-6 in Patients with EndometriosisAssociated Infertility |
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| DOI： |
| 中文关键词: 促性腺激素释放激素激动剂 维生素E 子宫内膜异位症 肿瘤坏死因子-α 白介素-6 |
| 英文关键词: Gonadotropin releasing hormone agonist Vitamin E Endometriosis TNF-α IL-6 |
| 基金项目:陕西省自然科学基金项目(2011JQ4025)；国家自然科学基金项目（30719004） |
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| 中文摘要: |
| 目的：探讨促性腺激素释放激素激动剂联合维生素E 对子宫内膜异位症伴不孕女性血清肿瘤坏死因子（TNFα）及白介素-6
（IL-6）水平的影响。方法：收集我院治疗的84 例子宫内膜异位症伴不孕患者，随机分为实验组和对照组，每组42 例。对照组患者
给予促性腺激素释放激素激动剂治疗，实验组患者在对照组基础上给予维生素E 治疗。观察并比较两组患者治疗前后血清
TNF-α及IL-6 水平、妊娠率以及临床疗效。结果：与治疗前比较，两组患者治疗后血清IL-6 及TNF-琢水平均下降，差异具有统计
学意义(P<0.05)；与对照组比较，实验组患者治疗后血清TNF-α及IL-6 水平较低，差异具有统计学意义(P<0.05)。实验组患者治疗
总有效率(92.86%)高于对照组(78.57%)，差异具有统计学意义(P<0.05)。实验组患者妊娠率(71.43%)高于对照组(54.76)，差异具有
统计学意义(P<0.05)。结论：促性腺激素释放激素激动剂联合维生素E 能够降低子宫内膜异位症伴不孕女性血清TNF-α及IL-6
水平，提高患者的妊娠率，临床效果较好。 |
| 英文摘要: |
| Objective:To investigate the effect of gonadotropin releasing hormone agonist combined with vitamin E on serum levels
of TNF-αand IL-6 in patients with endometriosis associated infertility.Methods:84 cases of endometriosis associated infertility in our
hospital were selected and randomly divided into the experimental group and the control group with 42 cases in each group. Patients in
the control group were treated with gonadotropin releasing hormone agonist, 2.5mg/ times, 1 time / month. The experimental group were
given vitamin E 14mg/d for 3 months on the basis of the control group. After the treatment, the serum levels of TNF-α, IL-6, and the
pregnancy status of the patients were detected and compared.Results:Compared with before treatment, the serum IL-6 and TNF-琢levels
were decreased after treatment of the two groups , and the difference is statistically significant (P<0.05); compared with the control group,
the serumTNF-αand IL-6 levels was lower after treatment in the experimental group, the difference is statistically significant (P<0.05). In
the experimental group, the total effective rate (92.86%) was higher than that in the control group (78.57%), and the difference was statistically
significant (P<0.05). The pregnancy rate (71.43%) in the experimental group was higher than that in the control group (54.76), and
the difference was statistically significant (P<0.05).Conclusion:Gonadotropin releasing hormone agonist combined with vitamin E can
reduce the level of serumTNF-α and IL-6 in endometriosis associated infertility women, improve the pregnancy rate of patients, the clinical
effect is good. |
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