欢迎访问《现代生物医学进展》编辑部！

目的：探讨不稳定型心绞痛（unstable angina pectoris,UAP）、急性心肌梗死（acute myocardial infarction,AMI）患者血小板指标、超敏C反应蛋白（C-reactive protein，hs-CRP）水平变化及意义。方法：选取于我院进行治疗的急性冠脉综合征患者300 例中UAP 患者121 例（UAP组），AMI患者179 例（AMI组）。另选100例健康体检者作为对照组。300 例急性冠脉综合征患者均口服阿司匹林进行治疗。服用阿司匹林7 d后比较各组血小板指标血小板聚集率、血小板膜糖蛋白CD62p、尿11-脱氢-血栓素B2(11-dehydro- Thromboxane，11-DH-TXB2)及hs-CRP水平变化，同时记录随访1 年急性冠脉综合征患者心血管事件发生情况。结果：治疗后 UAP 组、AMI 组二磷酸腺苷（adenosine diphosphate，ADP）及花生四烯酸（arochidonic acid，AA）诱导的血小板聚集率、 11-DH-TXB2 与对照组差异显著（P<0.05），AMI 组CD62p、hs-CRP水平均显著高于对照组（P<0.05）；随访1 年，11-DH-TXB2 水平≥ 1500 ng/g者心血管事件发生率为51.02 %，11-DH-TXB2 水平<1500 ng/g者心血管事件发生率为22.28 %，二者发生率差异显著（P<0.05）。结论：血小板指标、hs-CRP检测对UAP、AMI具有临床意义。

英文摘要:

Objective:To investigate the change and significance of Blood platelet indexes and hs-CRP in patients with UAP and AMI.Methods:A total of 300 acute coronary syndrome patients were randomly divided into UAP group (121 cases) and AMI group (179 cases), and 60 healthy adults were regarded as control group. The UAP and AMI groups received aspirin treatment. The effect on platelet aggregation rate, CD62p, urinary 11-DH-TXB2 and hs-CRP were compared before and after treatment in UAP and AMI groups, cardiovascular events was recorded 1 year follow-up.Results:After treatment, there was no significant difference in UAP and AMI groups (P>0.05), levels of platelet aggregation (AA and ADP) and urinary 11-DH-TXB2 in the AMI and UAP groups had significant difference in control group (P<0.05), levels of CD62p and hs-CRP in the AMI group were increased significantly than that in control group (P<0. 05); The cardiovascular events rate (11-DH-TXB2≥ 1 500 ng/g, 51.02 %) was, higher that (11-DH-TXB2<1500 ng/g, 22.28 %) (P<0.05).Conclusion:The detection of platelet indexes and hs-CRP has clinical significance in paients with UAP and AMI.

View Full Text View/Add Comment Download reader