| 全红艳 李东辉 郝建峰 张秀敏 田媛.化疗联合唑来膦酸对肺癌骨转移的疗效及炎性因子的影响[J].现代生物医学进展英文版,2016,16(31):6080-6083. |
| 化疗联合唑来膦酸对肺癌骨转移的疗效及炎性因子的影响 |
| Influence of Chemotherapy Combined with Zoledronic Acid on the Efficacyand Inflammatory Factors of Lung Cancer Bone Metastases |
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| DOI： |
| 中文关键词: 唑来膦酸 化疗 阵痛效果 活动能力 炎性因子 |
| 英文关键词: Zoledronic acid Chemotherapy Analgesic effect Activity ability Inflammation factors |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨化疗联合唑来膦酸对肺癌患者骨转移的疗效及炎性因子的影响。方法：回顾性选择我院2010 年1 月至2015 年
12 月收治的84例肺癌骨转移患者，根据随机数字表法结合患者意愿，将所有患者平均分为观察组与对照组，每组42 例。对照组
给予TP方案化疗2 个疗程，观察组在对照组基础上给予唑来膦酸治疗2 个疗程，观察两组患者治疗后的镇痛效果、活动能力、骨
转移灶效果、不良反应及治疗前后的IL-6、TNF-α水平。结果：观察组镇痛效果、活动能力、骨转移灶效果明显高于对照组（P<0.
05），观察组与对照组不良反应无统计学意义（P>0.05），与治疗前相比，治疗后两组患者的IL-6、TNF-α水平明显降低，与对照组相
比，治疗后治疗组的IL-6、TNF-α水平明显较低（P<0.05）。结论：化疗联合唑来膦酸治疗肺癌骨转移安全有效，可降低炎性因子的
释放，增强镇痛效果和活动能力，减缓骨转移。 |
| 英文摘要: |
| Objective:To investigate the clinical efficacy of chemotherapy combined with zoledronic acid in lung cancer with
bone metastases and its effect on inflammatory factors.Methods:84 lung cancer patients with bone metastasis from January 2010 to December
2015 in our hospital were chosen and divided into observation group and control group, 42 cases in each group. The control
group was given TP chemotherapy regimen for 2 courses, and the observation group were given zoledronic acid combined with
chemotherapy for 2 courses. The analgesic effect, activity ability, bone metastases effect, adverse reactions were detected, and the level of
IL-6 and TNF-α before and after treatment were observed and compared.Results:The analgesic effect, activity ability, bone metastases
effect in the observation group were higher than that of control group (P<0.05), the incidence of adverse reactions of two groups had no
significant difference (P>0.05), the IL-6 and TNF-αlevel in two groups after treatment was obviously lower than before treatment, and
the IL-6 and TNF-αin the observation group were lower than that of control group (P<0.05).Conclusion:Chemotherapy combined with
zoledronic acid can reduce the inflammation factors release, enhance the analgesic effect and activity ability, and alleviate bone metastases. |
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