| 张婧 丁煜倢 张耀莉 陈宁宁 罗明英.2 型糖尿病合并高血压患者发生心房颤动的相关因素分析[J].现代生物医学进展英文版,2016,16(31):6051-6054. |
| 2 型糖尿病合并高血压患者发生心房颤动的相关因素分析 |
| Related Factors Analysis of Atrial Fibrillation in Type 2 Diabetes Mellitus Patients with Hypertension* |
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| DOI： |
| 中文关键词: 糖尿病 心房颤动 危险因素 |
| 英文关键词: Diabetes Atrial fibrillation Risk factor |
| 基金项目:国家自然科学基金项目（81500377） |
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| 中文摘要: |
| 目的：探讨2 型糖尿病合并高血压住院患者发生心房颤动的相关因素。方法：选取我院收治的2 型糖尿病合并高血压发生
心房颤动的患者112 例为研究对象(房颤组，n=112 例)，同期选取与房颤组年龄及性别相匹配的未发生房颤的2 型糖尿病合并高
血压患者150 例为对照组(n=150 例)，比较两组患者的一般临床资料、实验室检查指标等的差异，用Logistic 回归方程分析患者并
发房颤的相关因素。结果：与对照组比较，房颤组患者收缩压(SBP)较高，高血压比例高、服用ACEI/ARB 类药物偏低(P＜0.05)、左
室射血分数(LVEF)偏低(P＜0.05)、左房内径(LAD)长(P＜0.05)、甘油三酯(TC)、低密度脂蛋白胆固醇(LDL-C)、糖化血红蛋白
(HbA1c)、血肌酐(Scr)、B 型脑钠肽(BNP)、高敏C 反应蛋白(hs-CRP)、尿酸均较高(P＜0.05)；多因素Logistic 回归方程分析提示：
LAD、HbA1c、BNP、hs-CRP、尿酸是患者并发房颤的独立危险因素(P＜0.05)，而服用ACEI/ARB 类药物为保护性因素。结论：
LAD、HbA1c、BNP、hs-CRP、尿酸均可能是2 型糖尿病合并高血压患者发生心房颤动的独立危险因素。 |
| 英文摘要: |
| Objective:To investigate the related factors of atrial fibrillation for hospitalized patients with type 2 diabetes mellitus
and hypertension ertension.Methods:112 cases of atrial fibrillation patients combined with type 2 diabetes mellitus and hypertension
were taken as the research objects, and, named as atrial fibrillation group (n=112). At the same time, 150 cases of patients with type 2 diabetes
mellitus and hypertension whose age and gender were matched with the atrial fibrillation group but had no atrial fibrillation were
selected as control group (n=150). The clinical data and laboratory examination indexes were compared, and factors associated with atrial
fibrillation complication were analyzed by using Logistic regression equation.Results:Compared with control group, patients in atrial
fibrillation group had high systolic blood pressure (SBP), high proportion of hypertension, low proportion of taking ACEI/ARB drugs
(P<0.05), low left ventricular ejection fraction (LVEF) (P<0.05), long left atrial diameter (LAD) (P<0.05), and high levels of triglycerides
(TC), low-density lipoprotein cholesterol (LDL-C), glycosylated hemoglobin (HbA1c), serumcreatinine (Scr), b-type brain natriuretic
peptide (BNP), high-sensitivity c-reactive protein (hs CRP) and uric acid (P<0.05). Multiariable Logistic regression equation analysis
showed that LAD,HbA1c, BNP, hs CRP and uric acid were independent risk factors of patients complicated with atrial fibrillation (P<0.05),
while taking ACEI/ARB drugs was protective factors.Conclusion:LAD, HbA1c, BNP, hs CRP and uric acid may be independent risk
factors for patients with type 2 diabetes mellitus and hypertension complicated with atrial fibrillation. |
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