| 王康 宋志磊 梁欢 王倩 刘新荣 周绍兵 晏为力.钛- 载药纳米复合材料的组装及其性质的研究[J].现代生物医学进展英文版,2016,16(31):6010-6014. |
| 钛- 载药纳米复合材料的组装及其性质的研究 |
| The Characterization of a Selfassembly Titanium/drug-loading Nanoparticles Complex |
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| DOI： |
| 中文关键词: 钛 多巴胺 泊洛沙姆188 纳米粒 |
| 英文关键词: Titanium Dopamine Poloxamer188 Nanoparticles |
| 基金项目:国家自然科学基金面上项目（21574105）；四川省科技厅项目（2015JY0202）；
成都市科技惠民项目（2015-HM01-00047-SF）；四川省高校创新团队建设项目（14TD0050） |
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| 中文摘要: |
| 目的：构建一种能结合钛表面的载药纳米粒及钛- 载药纳米复合材料的组装和性质研究。方法：(1)多巴胺修饰的非离子表
面活性剂多巴胺-泊洛沙姆188(Dop-Poloxamer188)的合成和检测；(2)Dop-Poloxamer188 作为表面活性剂、PLGA作为油相基质，
制备纳米粒及纳米粒载药和表征；(3)钛片的预处理及钛片与修饰后的纳米粒的结合；(4)纳米粒修饰后的钛表面的表征。结果：新
合成的Dop-Poloxamer188 在285 nm左右有紫外吸收峰，说明多巴胺成功的修饰在Poloxamer188 的两端；Dop-Poloxamer188 能
和PLGA 制备出很好的纳米粒，平均粒径在110 nm左右，PDI小于0.1；多巴胺修饰的纳米粒与钛片通过简单的浸渍过程结合后，
通过水接触角、场发射扫面电镜(Fe-SEM)、荧光显微镜、X 射线光电子能谱(XPS)等仪器检测都显示多巴胺修饰的纳米粒成功且牢
固的修饰在钛片表面。结论：成功达到钛表面的载药纳米粒修饰的目的，为钛种植体的载药系统提供了新的思路和方法。 |
| 英文摘要: |
| Objective:To prepare and utilize a novel Titanium surface affinity drug loaded nanoparticles to build a Titanium/
nanoparticle complex which could be used for drug delivery and release.Methods:(1) The synthesis and characterization of
dopamine modified non-ionic surfactants, Dop-Poloxamer188. (2) Using Dop-Poloxamer188 as a surfactant, PLGA as oil phase matrix
and model drugs, drug-loaded nanoparticles were prepared and characterized. (3) With pretreatment of the titanium plate, Dop-functionalized
nanoparticles and titanium plate selfassembled into a Titanium/nanoparticles (Ti/NP). (4) The characterization of Ti/NP complex.Results:The new compound Dop - Poloxamer188 had an ultraviolet absorption peak at about 285 nm, indicating that the successful modification
of dopamine to Poloxamer188; the Dop-Poloxamer188-PLGA nanoparticels had an average diameter of around 110 nm with
polydispersity index (PDI) less than 0.1. Furthermore, Dopamine modified nanoparticles were immobilized on titanium surface through a
simple dipping process. Water contact angle test, field-emission scanning electron microscope (Fe-SEM), fluorescence microscopic analysis
and X-ray photoelectron spectroscopy (XPS) detection confirmed that dopamine modified nanoparticles were immobilized on titaniumsurface.Conclusion:This study successfully constructed a novel drug-loaded nanoparticles which could be immobilized on titanium
surface. The novel drug loaded Ti/NP complex had the potential to be used for site specific drug delivery and controlled release in the
broad area of Ti based biomaterials. |
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