杨伟国 李永红 徐辉 郭瑞 居军.ERα-29 位基因多态性与HBV相关原发性肝癌易感性的关系分析[J].现代生物医学进展英文版,2016,16(30):5908-5910. |
ERα-29 位基因多态性与HBV相关原发性肝癌易感性的关系分析 |
The Relationship between ERα-29 Gene Polymorphisms and HBV -relatedHepatocellular Carcinoma |
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DOI: |
中文关键词: ERα-29 HBV相关原发性肝癌 多态性 |
英文关键词: ERα-29 HBV-related hepatocellular carcinoma Polymorphisms |
基金项目: |
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中文摘要: |
目的:探讨ER琢-29 位基因多态性与HBV相关原发性肝癌(PHC)易感性的关系。方法:通过聚合酶链反应-限制性片段长度
多态性法检测我院100 例HBV 相关原发性肝癌患者(PHC 组)与95 例同期健康体检者(对照组)的ERα-29 位基因多态性并对
两组间各等位基因、基因型频率进行比较。结果:PHC组ERα-29 位基因的TT、TC 和CC 基因型分别有31 例(31.00%)、45 例
(45.00%)和24 例(24.00%),T 与C 等位基因频率分别为53.50%和46.50%,对照组ERα-29 位基因的TT、TC和CC型基因型分别
有11 例(11.58%)、39 例(41.05%)和45 例(47.37%),T 与C 等位基因频率分别为32.11%和67.89%,两组间基因型分布、等位基因
频率差异均具有统计学意义(P<0.05);T等位基因发生PHC 的风险是C 等位基因的2. 43 倍( OR =2.43,95%CI: 1.37~4.32) 。结
论:ERα-29 位基因与HBV 相关原发性肝癌易感性有关,其中T 等位基因可增加发生风险。 |
英文摘要: |
Objective:To explore the relationship between ERα-29 gene polymorphisms and HBV -related hepatocellular
carcinoma.Methods:polymerase chain reaction-restriction fragment length polymorphism was conducted to detect the ERα-29 gene
polymorphisms of 100 HBV-related hepatocellular carcinoma patients and 95 healthy people. The alleles and genotypes between these
two groups were compared.Results:The numbers of TT, TC and CC genotype of ERα-29 gene in the PHC group were 31 cases
(31.00%)、45 cases(45.00%)and 24 cases(24.00%), while the rate of T and C allele were 53.50%and 46.50%respectively. The numbers
of TT,TC and CC genotype of ERα-29 gene in the control group were 11 cases(11.58%),39 cases(41.05%)and 45cases(47.37%), while
the rate of T and C allele were 32.11% and 67.89% respectively.The rate of genotypes and alleles between these two groups all had
statistical difference(P<0.05). Compared to the C allele,the incidence of PHC of T allele carrier was 2.43 times higher(OR=2.43, 95%CI:
1.37~4.32).Conclusion:ERα-29 has a relationship with HBV-related hepatocellular carcinoma,and the T allele carrier can increase the
risk. |
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