| 马晶 吴东红△ 柳杰 刘大娜 陈萍.Graves病患者血清氧化应激水平的变化[J].现代生物医学进展英文版,2016,16(30):5890-5892. |
| Graves病患者血清氧化应激水平的变化 |
| A Study on the Relationship between Oxidative Stress and Graves' Disease |
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| DOI： |
| 中文关键词: Graves病 氧化应激 硝基酪氨酸 共轭双烯 |
| 英文关键词: Graves' disease Oxidative Stress Nitrotyrosine Conjugated dienes |
| 基金项目: |
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| 中文摘要: |
| 目的：检测Graves病患者血清氧化应激指标的变化，探讨甲亢与氧化应激的关系。方法：选择本院门诊及住院符合甲亢临床
及实验检查确诊的患者60 例作为Graves 病组(观察组，B 组)及同期健康对照者30 例作为正常对照组(对照组，A组)。其中B组
按照甲状腺激素水平各分为两组：B1 组：正常值＜fT3＜10 pg/mL 30 例；B2 组：fT3＞30 pg/mL 30 例。采用酶联免疫吸附法检测和
比较各组血清甲状腺激素、硝基酪氨酸、共轭双烯水平。结果：与对照组相比，Graves 病甲亢患者体内硝基酪氨酸、共轭双烯水平
增高（(P＜0.01)；正常对照组与B1 组、正常对照组与B2 组、B1 组与B2 组相比较，硝基酪氨酸、共轭双烯水平有差别，即甲状腺激
素水平相对较高者氧化应激程度较高(P＜0.05)；硝化酪氨酸与年龄、fT3、fT4 呈显著正相关，共轭双烯与年龄、fT3、fT4 呈显著正
相关。结论：Graves 病甲亢患者体内氧化应激水平随甲状腺激素水平不同而变化。 |
| 英文摘要: |
| Objective:To observe the levels of oxidative stress in the patients with Graves' disease and investigate the relationship
between oxidative stress and Graves' disease.Methods:In this study, 60 cases of patients admitted in the Health Examination Center and
Endocrine Division I ward of the first hospital of Harbin from December 2014 to September 2015 with Graves' disease were selected as
GD group(observation group, group B), 30 cases of healthy control were selected as the control group(group A). According to the level of
thyroxine hormone, group B was further divided into group B1 (normal value |
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