Article Summary
高琳 苏振丽 郑瑜 庞毅 李宝.2 型糖尿病患者尿微量白蛋白排泄率与eGFR 的关系及相关危险因素[J].现代生物医学进展英文版,2016,16(29):5763-5766.
2 型糖尿病患者尿微量白蛋白排泄率与eGFR 的关系及相关危险因素
Analysis of Relationship between Microalbuminuria Excretion Rate andeGFR in Patients with Type 2 Diabetic Mellitus and Related Risk Factors
  
DOI:
中文关键词: 2 型糖尿病  尿微量白蛋白排泄率  肾小球滤过率  危险因素
英文关键词: Type 2 diabetes  Urinary albumin excretion rate  Glomerular filtration rate  Risk factors
基金项目:陕西省宝鸡市卫生局科研立项(2012-16 号)
Author NameAffiliation
高琳 苏振丽 郑瑜 庞毅 李宝 陕西省宝鸡市中心医院老年病内分泌科陕西省宝鸡市中心医院检验科 
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中文摘要:
      目的:分析2 型糖尿病(T2DM)患者尿微量白蛋白排泄率(UAER)与肾小球滤过率(eGFR)的关系,并探讨相关的危险因素。 方法:选取我院收治的2 型糖尿病患者470 例,根据UAER 及eGFR的检查结果进行分组,收集患者的一般资料,研究UAER 与 eGFR 的关系,并分析其相关危险因素。结果:不同UAER体质量、体表面积、BMI,DBP,SBP,高血压病程、TG,TC,血肌酐以及尿 酸水平比较,差异有统计学意义(P<0.05)。不同eGFR 年龄、体质量、糖尿病病程、体表面积、BMI、高血压的病程、HbA1c,HDL-C, 血肌酐以及尿酸水平比较,差异有统计学意义(P<0.05)。大量清蛋白尿患者肾功能异常发生率最高,正常清蛋白尿患者肾功能异 常发生率最低,差异有统计学意义(P<0.05)。eGFR ≥ 90 mL·min-1·1.73 m-2患者正常、微量、大量清蛋白尿分别占82.08%、 13.68%、4.25%,根据交叉检验分析,UAER 与eGFR 间有相关性(P<0.05)。Logistic 回归分析结果显示,与UAER相关危险因素包 括血肌酐、收缩压及体质指数,与eGFR 相关危险因素包括年龄、体质量、血肌酐(P<0.05)。结论:UAER与eGFR 间存在相关性, 一并进行检测对早期诊断2 型糖尿病肾损伤有利。而两者相关危险因素包括血肌酐、收缩压及体质指数。
英文摘要:
      Objective:To analyze the relationship between urinary albumin excretion rate (UAER) and glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus (T2DM) and explore the related risk factors.Methods:470 patients with type 2 diabetes mellitus who were treated in our hospital were selected on the basis of the UAER and eGFR. Then the general information of patients was collected, and the relationship between UAER and eGFR and related risk factors were analyzed.Results:There was statistically significant difference about the body weight, body surface area, BMI, DBP, SBP, TG, TC, hypertension, serum creatinine and uric acid of patients with different UAER (P<0.05). There was statistically significant difference about the age, body mass, diabetes duration, body surface area, BMI, hypertension, HbA1c, HDL-C, serum creatinine and uric acid levels of patients with different eGFR (P<0.05). The incidence rate of abnormal renal function was highest in patients with large quantity of albuminuria and lowest in patients with normal albuminuria, and the difference was statistically significant (P<0.05). Patients of eGFR ≥ 90ml·min-1·1.73m-2 with normal, small amount of and large quantity of albuminuria accounted for 82.08%, 13.68% and 4.25%, respectively. According to the cross validation analysis, UAER and EGFR were correlated (P<0.05). Logistic regression analysis showed that the risk factors of UAER included serum creatinine, systolic blood pressure and BMI, and the risk factors of eGFR were age, body mass and serum creatinine (P<0.05).Conclusion:There is correlation between UAER and eGFR, and the combined detection should be conducive to early diagnosis of type 2 diabetic renal injury. The related risk factors include serumcreatinine, systolic blood pressure and BMI.
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