| 王海波 曹文慧 安宁 赵维纳 李晶超.微创介入治疗对急性脑梗死患者血清相关细胞因子及生活质量的影响[J].现代生物医学进展英文版,2016,16(29):5730-5732. |
| 微创介入治疗对急性脑梗死患者血清相关细胞因子及生活质量的影响 |
| Influence of Minimally Invasive Interventional Therapy on SerumRelatedCytokines and Quality of Life in Patients with Acute Cerebral Infarction |
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| DOI： |
| 中文关键词: 急性脑梗死 介入治疗 内皮生长因子 神经营养因子 神经生长因子 生活质量 |
| 英文关键词: Acute cerebral infarction Interventional therapy Endothelial growth factor Neurotrophic factor Nerve growth factor Quality of life |
| 基金项目:牡丹江医学院科学技术研究项目（ZS201506） |
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| 中文摘要: |
| 目的：探讨微创介入治疗对急性脑梗死患者血清相关细胞因子及生活质量的影响。方法：选择2014 年10 月-2016 年4月我
院收治的70 例急性脑梗死患者作为研究对象，按照数字列表法随机分为观察组和对照组，各35 例，对照组给予药物溶栓保守治
疗及常规治疗，观察组在常规治疗基础上行脑血管球囊成形支架置入术，比较两组患者治疗前后血管内皮生长因子（VEGF）、神
经营养因子（NTF）、神经生长因子（NGF）水平，并采用SF-36 量表评价两组患者治疗前后生活质量。结果：①治疗后两组患者
VEGF、NTF及NGF水平均显著高于治疗前，且观察组均显著高于对照组，比较差异均有统计学意义（均P＜0.05）；②治疗后两组
患者SF-36 总分显著高于治疗前，且观察组显著高于对照组，比较差异有统计学意义（P＜0.05）。结论：采用微创介入治疗急性脑
梗死患者，能够显著提高其血清相关细胞因子水平，并明显改善患者生活质量，值得临床推广。 |
| 英文摘要: |
| Objective:To investigate the influence of minimally invasive interventional therapy on serum related cytokines and
quality of life in patients with acute cerebral infarction.Methods:A total of 70 patients with acute cerebral infarction were selected as the
research objects in our hospital from October 2014 to April 2016, they were divided into observation group and control group with 35
cases in each group according to the randomnumber table method, the control group was given thrombolytic drug conservative treatment
base on conventional therapy, while the observation group was underwent minimally invasive interventional therapy base on conventional
therapy, then compared the levels of vascular endothelial growth factor(VEGF), neurotrophic factor (NTF), nerve growth factor(NGF)
in two groups before and after treatment, and applied the SF-36 scale to evaluated the quality of life in two groups before and after treatment.Results:① The levels of VEGF, NTF and NGF in the two groups after treatment were significantly higher than before treatment,
and observation group were significantly higher than control group,the differences were statistically significant(P<0.05); ②The SF-36 total
scores after treatment in two groups were significantly higher than before treatment, which in the observation group were significantly
higher than control group,the differences were statistically significant(P<0.05).Conclusion:Using minimally invasive interventional therapy
in the treatment of patients with acute cerebral infarction can significantly improve the serum related cytokines levels,and obviously
improve the quality of life of patients, which is worth clinical promotion. |
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