| 魏占云 李耘 杨伟△ 张艳红 张丽.血清尿酸、超敏C 反应蛋白与老年永久性房颤的关系[J].现代生物医学进展英文版,2016,16(29):5644-5647. |
| 血清尿酸、超敏C 反应蛋白与老年永久性房颤的关系 |
| Correlation between SerumUric Acid Level, Hypersensitive C-reactiveProtein, Left Atrial Diameter and Atrial Fibrillation in Elderly Patients |
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| DOI： |
| 中文关键词: 心房颤动 尿酸 超敏C 反应蛋白 左心房内径 氧化应激 |
| 英文关键词: Atrial fibrillation Serumuric acid Hypersensitive c-reactive protein Left atrial diameter Oxidative stress |
| 基金项目:北京市卫计委保健专项课题（13-01） |
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| 中文摘要: |
| 目的：探讨血清尿酸（UA）、超敏C 反应蛋白（hs-CRP）、左心房内径（LAD）与老年永久性房颤的相关性。方法：选取2012 年8
月至2015 年9 月于首都医科大学宣武医院综合科住院的老年永久性房颤患者78 例作为房颤组，选取同期住院窦性心律且无房
颤病史的老年患者72 例作为对照组，记录各组一般资料及超声心动图、尿酸、hs-CRP 水平等，进行比较及相关性分析。结果：①与
对照组相比，房颤组血清UA及hsCRP水平、左心房内径大小明显增高(P＜0.05)，②以房颤是否发生为因变量，多因素logistic 回
归分析显示血清尿酸（OR=2.016，P=0.004）、左房内径（OR=4.180，P=0.001）和hs-CRP（OR=2.846，P=0.002）是老年永久性房颤发生
的独立危险因素。③房颤组患者血清尿酸与hs-CRP水平呈正相关（r=0.28，P＜0.05），尿酸与左心房内径大小呈轻度正相关（r=0.
12，P＜0.05）。结论：血清尿酸、hs-CRP、左房内径是老年永久性房颤发生的独立危险因素；尿酸参与的炎症反应和结构重构可能参
与老年永久性房颤的发生。 |
| 英文摘要: |
| Objective:To investigate the correlation between serumuric acid (UA), high sensitive C reactive protein (hs-CRP), left
atrial diameter (LAD) and permanent atrial fibrillation (AF) in the elderly.Methods:78 patients with AF were enrolled in Xuanwu Hospital
of Capital University of Medical Sciences Department of General Hospital from August 2012 to September 2015. And 72 cases of elderly
patients with no history of atrial fibrillation in Xuanwu Hospital were chosen as control group during the same period. The levels of
uric acid (UA), hs-CRP were detected, left atrial diameter (LAD) the left ventricular end-diastolic diameter (LVEDD), left ventricular
ejection fraction (LVEF) were measured using color Doppler ultrasound. The data were analyzed and compared between two groups.Results:① Compared with control group, the serum levels of UA, hs-CRP level, left atrial diameter size was significantly increased (P<
0.05) in atrial fibrillation (AF) group. ② Logistic regression analysis showed that serum uric acid (OR=2.016, P=0.004), left atrial diameter
(OR=5.180, P=0.001) and hs-CRP (OR=2.846, P=0.002) were the independent risk factors of elderly permanent atrial fibrillation. ③
The level of serum uric acid was positively correlated (r=0.28, P<0.05) with hs-CRP level, and was mild positively correlated (r=0.12,
P<0.05) with left atriumdiameter.Conclusion:The serumUA, hs CRP and left atrial diameter are the independent risk factors of elderly
permanent atrial fibrillation; and might participate in the occurrence of atrial fibrillation via the inflammatory reaction and structural remodeling. |
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