| 赵白桦 刘明辉 刘成晓 蒲大容 戴茜.应变率成像技术评价吗啡预处理对兔心肌缺血再灌注损伤时左室功能的影响[J].现代生物医学进展英文版,2016,16(29):5610-5615. |
| 应变率成像技术评价吗啡预处理对兔心肌缺血再灌注损伤时左室功能的影响 |
| Evaluation of Morphine Preconditioning on the Left Ventricular Function in aRabbit Model of Ischemia-reperfusion Injury by SRI |
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| DOI： |
| 中文关键词: 心肌缺血再灌注 吗啡预处理 应变率成像 |
| 英文关键词: Myocardial ischemia reperfusion Morphine preconditioning Strain rate imaging |
| 基金项目:湖南省自然科学基金项目（12JJ3102） |
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| 中文摘要: |
| 目的：应用应变率成像技术(SRI)动态观察和评价吗啡预处理对兔心肌缺血再灌注损伤时左室长轴功能的影响。方法：建立
新西兰大白兔心肌缺血再灌注模型，随机分为假手术组(SH 组)、吗啡预处理组(MF组)和生理盐水预处理组(NS 组)。于手术前1
天及手术术后28 天内不同时间点测量超声心动图常规数据及左室各壁收缩期峰值速度与应变率参数。结果：术后1 天，MF组与
NS 组左室整体与局部心肌收缩功能较术前和SH 组明显减低(P<0.05)，并随缺血再灌注时间的延长呈减低趋势(P<0.05)，且NS
组减低更明显(P<0.05)。结论：SRI技术能够客观、准确地评价缺血再灌注损伤心肌的局部收缩功能的变化，而吗啡预处理对兔心
肌缺血再灌注损伤存在明显的弱化作用。 |
| 英文摘要: |
| Objective:To analyze the dynamic change of left ventricular longitudinal function in a rabbit model of myocardium ischemia-
reperfusion with morphine preconditioning through strain rate imaging(SRI).Methods:A myocardiumischemia-reperfusion model
was induced by occlusion and recanalization of coronary artery in forty male New Zealand white rabbits, which were randomly divided
into the sham operated group (SH), morphine preconditioning ischemia reperfusion group (MF) and normal saline preconditioning ischemia
reperfusion group (NS). Routine echocardiography datas and dynamic images were collected on 1 day before and within 28 days
after the operation. All of these images were analyzed off-line using TDI software to survey the parameters, including the systolic velocity
and systolic strain rate.Results:On the 1st day after operation, the global and regional systolic function of left ventricle of group MF and
group NS were lower than those preoperation and in group SH (P<0.05), as time went, the above-mentioned parameters decreased gradually
after ischemia reperfusion (P<0.05), which were more obviously in group NS (P<0.05).Conclusion:It was objective and accurate to
detect the variance of regional myocardial function in myocardial ischemia reperfusion injury using strain rate imaging. Strain rate imaging
becomes a reliable and non-invasive method of evaluating myocardial function in clinic. Morphine preconditioning could apparently
attenuate the myocardial ischemia reperfusion injury in rabbits. |
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