| 孟繁森 米洁 孙全贵 海春旭 王欣.肝细胞核因子在2型糖尿病发生中的作用研究新进展[J].现代生物医学进展英文版,2016,16(28):5590-5592. |
| 肝细胞核因子在2型糖尿病发生中的作用研究新进展 |
| Novel Role of Hepatocyte Nuclear Factor in Type 2 Diabetes Mellitus |
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| DOI： |
| 中文关键词: 肝细胞核因子 2 型糖尿病 胰岛素抵抗 胰岛β细胞损伤 |
| 英文关键词: Hepatocyte nuclear factor Type 2 diabetes mellitus Insulin resistance β-cell dysfunction |
| 基金项目:国家自然科学基金青年基金项目（31400724）；陕西省自然科学基金青年基金项目（2014JQ4135） |
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| 中文摘要: |
| 肝细胞核因子（Hepatocyte nuclear factors，HNFs）是一类分布在肝、胰、肠、肾等多个组织器官，调节肝脏内基因特异性表达
的一类转录因子。其主要亚型为HNF1、HNF3、HNF4 和HNF6 等，这些转录因子相互作用构成的复杂调控网络。2 型糖尿病（Type
2 diabetes mellitus，T2DM）的基本病理生理机制是胰岛素抵抗及胰岛茁细胞损伤，最终导致高血糖。近年来的研究表明，HNFs 在
胰岛素抵抗及胰岛β细胞损伤中发挥关键的调控作用。本文对HNFs在T2DM 发生中的胰岛素抵抗及胰岛β细胞损伤作用研究
新进展作以回顾性综述，旨在为认识T2DM 发病机制及提出防治策略提供理论基础。 |
| 英文摘要: |
| Hepatocyte nuclear factors (HNFs) are a group of transcription factors that express in some important human organs,
such as liver, pancreas, intestines, kidney and play important roles in regulating transcription of the liver-specific genes, including HNF1,
HNF3, HNF4 and HNF6. These factors form a complicated hierarchical network. The hallmarks of type 2 diabetes mellitus include
insulin resistance (IR), β-cell dysfunction, and lead to hyperglycemia finally. Recent studies have shown that HNFs significantly regulate
IR and β-cell dysfunction. In this review, the novel progress in role of HNFs in the development of T2DM including insulin resistance
and β-cell dysfunction was summarized with the purpose of providing theoretical basis for further study of the mechanismand preventive
treatment of T2DM. |
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