| Objective:To evaluate the serum Zinc finger BED domain-containing protein 3 (ZBED3) levels in patients with
different glucose tolerance and disscuss the relationships between ZBED3 and metabolism index.Methods:The subjects were divieded
into three groups: type 2 diabetes mellitus (T2DM, n=115), impaired glucose tolerance (IGT, n=97), and normal glucose tolerance (NGT,
n=109). Serum ZBED3 levels were measured by ELISA. Insulin levels were measured by radioimmunoassy, lipids levels were measured
by ELISA. The relationships between plasma ZBED3 levels and physical/biochemical indicators, such as blood pressure,waist hip ratio
(WHR)，blood lipid, blood glucose, plasma insulin levels, body mass index (BMI)，glycosylated hemoglobin (HbA1C) and so on were
analyzed.Results:SerumZBED3 levels were significantly higher in women than that in men (121.3± 33.5 pg/mL vs 113.9± 32.9 pg/mL,
P =0.02). Significantly higher ZBED3 levels were also observed in overweight patients when compared with lean individuals (132.5±
31.4 pg/mL vs 111.4± 30.2 pg/mL, P =0.00). The serum ZBED3 levels were higher in type 2 diabetes group when compared with IGT
and NGT groups (143.5± 31.2 pg/mL vs 123.7± 26.4 pg/mL, 97.1± 20.3 pg/ml, P =0.00). In a combined population of all three groups,
there was a significant positive correlation between ZBED3 and BMI, WHR, BF%, SBP, DBP, TG, FBG, Fins, HbA1c, and HOMA-IR
(P < 0.01), while an inverse relationship of ZBED3 with HDL-C (P < 0.01). Moreover，logistic analysis showed that WHR, BF%, DBP,
TG, HbA1c, and HOMA-IR were independently related to serumZBED3 level.Conclusion:The serum ZBED3 levels were significantly
increased in T2DM, IGT patients and overweight population, and closely related to the development of obesity and T2DM. |
