| 张凌玲 王素娟 龙再菊 陈丽蓉 陶凤杰.益生菌对肠易激综合征患者肠道微环境及免疫功能的影响[J].现代生物医学进展英文版,2016,16(28):5552-5555. |
| 益生菌对肠易激综合征患者肠道微环境及免疫功能的影响 |
| Effects of Probiotics on Intestinal Microenvironment and Immune Function in Patients with Irritable Bowel Syndrome |
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| DOI： |
| 中文关键词: 肠易激综合征 益生菌 肠道微环境 免疫功能 |
| 英文关键词: Irritable bowel syndrome Probiotics Intestinal microenvironment Immune function |
| 基金项目:辽宁省科技厅计划项目(2013226012) |
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| 中文摘要: |
| 目的：探讨益生菌对肠易激综合征患者肠道微环境及免疫功能的影响，为临床相关研究提供参考。方法：选择2013 年6 月
-2015 年6 月在我院接受治疗的肠易激综合征患者79 例作为研究对象，根据治疗方案不同分为研究组（47 例）和对照组（42 例）。
研究组患者采用双歧三联活菌联合美沙拉嗪治疗，对照组患者给予美沙拉嗪治疗。观察并比较两组患者治疗前后肠道内肠杆菌、
双歧杆菌、乳酸杆菌、粪肠球菌及类杆菌的变化情况，以及血清CD4+，CD8+及CD4+/ CD8+水平，并评价两组的临床疗效。结果：治
疗前，两组患者肠道菌群数量比较，差异无统计学意义（P>0.05）；治疗后，两组患者肠道内大肠杆菌及粪肠球菌数量均减少，且研
究组少于对照组，差异具有统计学意义（P<0.05）；治疗后，两组患者肠道内乳酸杆菌、双歧杆菌和类杆菌数量均增加，且研究组高
于对照组，差异具有统计学意义（P<0.05）。治疗前，两组患者免疫功能指标比较，差异无统计学意义（P＞0.05）；治疗后，两组患者
CD4+T 细胞以及CD4+/ CD8+均显著高于治疗前，而CD8+T 细胞显著降低，差异具有统计学意义（P<0.05）；治疗后，研究组患者
CD4+ T 细胞及CD4+/CD8+均高于对照组，而CD8+T 细胞低于对照组，差异具有统计学意义（P<0.05）。研究组患者的临床疗效
（91.67%）高于对照组（76.67%），但两组比较，差异无统计学意义（P>0.05）。结论：益生菌制剂治疗不仅能够调节肠易激综合征患
者肠道内的菌群平衡，而且能够改善患者的免疫功能，值得临床推广应用。 |
| 英文摘要: |
| Objective:To investigate the effect of probiotics on intestinal microenvironment and immune function in patients with
irritable bowel syndrome, and provide reference for clinical research.Methods:79 patients with irritable bowel syndrome who were
treated in our hospital from June 2013 to June 2015 were selected as the research objects, and according to the different treatment
regimens, the patients were divided into the study group (47 cases) and the control group (42 cases). The patients in the study group were
treated with bifidobacteria and mesalamine, while the patients in the control group were treated with mesalamine. Then the intestinal
enterobacteriaceae, , , and , and the levels of CD4 + and CD8 + and CD4 + /
CD8 + were observed and compared between the two groups before and after treatment, and the clinical efficacy was evaluated.Results:Before treatment, there was no statistically significant difference about the intestinal microflora between the two groups (P>0.05); After
treatment, the intestinal and in the two groups reduced, and the study group was lower than that of
the control group, and the differences were statistically significant (P<0.05); After treatment, the intestinal ,
and in the two groups increased, and the study group was higher than that of the control group, and the differences were
statistically significant (P<0.05). Before treatment, there was no statistically significant difference about the indicators of immune
function between the two groups (P>0.05); After treatment, the levels of CD4 + T cells and CD4 + / CD8 + in the two groups were
significantly higher than before, and the study group was higher than that of the control group, and the differences were statistically
significant (P<0.05); After treatment, the levels of CD8 +T cells were lower than before, and the study group was lower than that of the
control group, and the differences were statistically significant (P<0.05); The clinical effect of the study group was 91.67%, which was
higher than 76.67% of the control group, while there was no significant difference between the two groups (P>0.05).Conclusion:Probiotics treatment can regulate the intestinal flora balance, and improve the immune function in patients with irritable bowel syndrome,
which is worthy of clinical application. |
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