| 卢军 曾其昌 王琴 彭琼 黄亚辉.托吡酯与丙戊酸钠对癫痫患儿脑电活动及糖脂代谢的影响[J].现代生物医学进展英文版,2016,16(28):5546-5548. |
| 托吡酯与丙戊酸钠对癫痫患儿脑电活动及糖脂代谢的影响 |
| Influence of Topiramate and SodiumValproate on EEG Activity and Glucoseand Lipid Metabolismof Epileptic Children |
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| DOI： |
| 中文关键词: 托吡酯 丙戊酸钠 癫痫 脑电活动 代谢指标 |
| 英文关键词: Topiramate Sodiumvalproate Epileptic Brain electrical activity Metabolic index |
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| 中文摘要: |
| 目的：探讨托吡酯与丙戊酸钠对癫痫患儿脑电活动及相关代谢指标的影响。方法：选择66 例癫痫患儿进行研究，并采用随机
方法分为两组，其中观察组予托吡酯治疗，对照组予丙戊酸钠治疗。比较治疗前后患儿脑电活动及糖脂代谢指标差异。结果：治疗
后，观察组患儿癫痫样放电(6.77± 1.04)次、δ (12.77± 2.32)次、θ (21.63± 2.77)次、琢(20.54± 2.55)次、茁(11.18± 1.72)次均较治疗前
和对照组明显减少(P<0.05)。观察组患儿经治疗后体质指数(BMI)(14.43± 1.29)kg/m2、空腹血糖(FPG)(4.53± 0.51)mmol/L较治疗前
和对照组明显减少(P<0.05)，空腹胰岛素(FINS)(9.78± 1.44)mU/L较治疗前和对照组明显增加(P<0.05)。两组患者经治疗后脂代谢
各项指标甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(L-DLD)、高密度脂蛋白(H-DLD)均较治疗前无明显变化(P>0.05)，且两组间
比较无显著差异(P>0.05)。结论：托吡酯能更有效控制癫痫患儿的脑电活动，但会导致糖代谢异常及患儿体质量指数减少，而丙戊
酸钠对癫痫患儿糖脂代谢及体质量指数的影响较小，临床应根据具体情况合理选择用药。 |
| 英文摘要: |
| Objective:To explore the influence of topiramate and sodium valproate on EEG activity and glucose and lipid
metabolism of epileptic children.Methods:66 cases of epileptic children were randomly divided into two groups. The observation group
was treated with topiramate, while the control group was treated with sodiumvalproate. The brain electrical activity and glucose and lipid
metabolism were compared before and after treatment.Results:After treatment, the epileptic discharges (6.77± 1.04), delta (12.77±
2.32), theta (21.63± 2.77), alpha (20.54± 2.55), beta (11.18± 1.72) of observation group were decreased significantly compared with
those before treatment and control group (P<0.05). After treatment, BMI (14.43± 1.29) kg/m2, FPG (4.53± 0.51) mmol/L of observation
group were significantly decreased (P<0.05), FINS (9.78± 1.44) mU/L was significantly increased (P<0.05) compared with that before
treatment. After treatment, the two groups of patients of lipid metabolism of TG, LDL-C, TC, HDL-C were significantly less than before
treatment (P>0.05), and there was no significant difference between the two groups (P>0.05).Conclusion:Topiramate could more
effectively control the EEG activity of epileptic children, but it could lead to a reduction in glucose metabolism and children's body mass
index (BMI). Sodium valproate had little influence on the glucose and lipid metabolism and body mass index of epileptic children. Drugs
should be rationally applied according to the specific situation. |
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