| 张子东 贾广志 李建明 王泽鑫 关利君 秦效军.子宫肌瘤动脉栓塞术改善子宫肌瘤患者预后与生活质量研究[J].现代生物医学进展英文版,2016,16(28):5460-5463. |
| 子宫肌瘤动脉栓塞术改善子宫肌瘤患者预后与生活质量研究 |
| The Research of Outcome and Quality of Life after Uterine ArteryEmbolization |
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| DOI： |
| 中文关键词: 子宫肌瘤动脉栓塞术 预后 生活质量 |
| 英文关键词: Uterine artery embolization Outcomes Quality of life |
| 基金项目:内蒙古自治区自然科学基金项目（2009ms1218） |
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| 中文摘要: |
| 目的：评估子宫肌瘤动脉栓塞术（UAE）改善子宫肌瘤患者预后与生活质量。方法：选取在我院介入科住院治疗的400 例子宫
肌瘤患者，记录患者的再干预率和出血有关的临床症状。将症状持续、恶化、症状复发和再干预定义为治疗失败（TF）。使用
Kaplan-Meier分析计算成功治疗的累积率。运用Cox 回归分析计算临床或形态学预测因子。评估患者生活质量和更年期的变化
情况。结果：400例患者中，328 例患者（82.0%）完成随访。共有54 例TF，对其中46例进行了再干预治疗。Kaplan-Meier分析表明，
5 年后TF累积率为23.3%。Cox 回归分析表明，与45 岁以上女性相比，40岁以下女性更易发生TF（OR=2.29，95%CI：1.02-5.19，
P=0.048）。非TF患者治疗后疾病相关生活质量显著改善（P<0.001）。274 例非TF患者中，有62（22.6%）例停经平均年龄为52 岁。
结论：UAE 可以对83.5%的子宫肌瘤患者相关的症状予以长期控制，并使其生活正常化。与接近绝经期妇女相比，TF在年轻女性
中的发生率更高。 |
| 英文摘要: |
| Objective:To evaluate the outcome and quality of life of patients after uterine artery embolization.Methods:A total of
400 patients with uterine fibroids treated in our hospital were included. The intervention rate and the clinical symptoms associated with
bleeding all were calculated and recorded. Persistence, worsening or recurrence of symptoms and re-interventions were classified as
treatment failure (TF). Kaplan-Meier analysis was applied to determine the cumulative rate of TF. Cox regression was used to identify
possible clinical or morphologic predictors of outcome. The quality of life and menopause changes were also evaluated.Results:Of the
400 patients, 328 (82%) patients were followed up. 54 patients had treatment failure, and 46 of them had re-intervention therapy.
Kaplan-Meier analysis showed that the cumulative rate of TF after 5 years was 23.3%. Cox regression analysis showed that patients under
40 years of old were more likely to get TF (OR=2.29, 95%CI: 1.02-5.19, P=0.048) than those over 45 years of old. The quality of life of
non-TF patients after treatment was significant improved. Among the 274 cases of non-TF patients, average age of 62 (22.6% )
menopause patients was 52 years.Conclusion:UAE leads to long-term control of fibroid-related symptoms and normalization of quality
of life in approximately 83.5%of patients. Younger women seemto have a higher risk of TF than older women closer to menopause. |
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