| 于丽倩 李晓云 陈丽艳 王巍 王英炜.标准剂量与小剂量美罗华在原发免疫性血小板减少症治疗中的临床研究[J].现代生物医学进展英文版,2016,16(27):5300-5302. |
| 标准剂量与小剂量美罗华在原发免疫性血小板减少症治疗中的临床研究 |
| Clinical Research of Standard Doses and Small Dose of Mabthera in theTreatment of Primary Immune Thrombocytopenia |
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| DOI： |
| 中文关键词: 小剂量 标准剂量 美罗华 原发免疫性血小板减少症(ITP) |
| 英文关键词: Small doses Standard dose Mabthera ITP |
| 基金项目:黑龙江省卫生厅科研基金项目（2013055） |
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| 中文摘要: |
| 目的：比较标准剂量美罗华与小剂量美罗华治疗原发免疫性血小板减少症(ITP)中的临床疗效及安全性。方法：选取哈尔滨
医科大学附属第一、第二医院自2010 年-2015 年常规治疗无效的原发免疫性血小板减少症(ITP)患者，共18例，分为两个实验组，
分别给予应用标准剂量美罗华(375 mg/m2，每周1 次，共4 次) ，患者8 例，小剂量美罗华( 每次100mg，每周1 次，共4 次) ，患者10
例，观察两组患者临床效果、治疗前后血小板水平及不良反应的发生情况。结果：小剂量美罗华治疗4 周后有效率较标准剂量无
明显差别(P>0.05)；小剂量美罗华治疗ITP不良反应率相对标准剂量要显著降低低(P＜0.05)。结论：小剂量美罗华治疗原发免疫性
血小板减少症(ITP)的临床疗效与标准剂量美罗华相当，但安全性更高。 |
| 英文摘要: |
| Objective:To compare the clinical efficacy and safety of standard dose and small dose of mabthera on primary immune
thrombocytopenia (ITP).Methods:A total of 18 cases of primary immune thrombocytopenia (ITP) patients who were treated in the
first, second affiliated hospital of Harbin medical university from 2010-2015 and was invalid to regular treatment were divided into two
group, respectively give application standard dose mabthera (375 mg/m2, 1 times a week, a total of 4 times), 8 cases, small dose of
mabthera (100 mg each time, once a week, a total of 4 times), 10 cases of patients, the clinical effect platelet levels before and after treatment
and the occurrence of adverse reactions of two groups were observed and compared.Results:No obvious difference was found in
the effective rate between standard dose and small dose of mabthera after 4 weeks' treatment(P>0.05); the incidence rate of adverse reactions
was significantly lower in the mall doses of mabthera than that of the standard doses (P<0.05).Conclusion:Small dose and standard
doses of mabthera had equal efficacy in the treatment of primary(ITP), but security was higher. |
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