| 李超 关颖 龙彩凤 徐以拓 董亚强 阿拉坦高勒△.鞘氨醇1- 磷酸受体4 研究进展[J].现代生物医学进展英文版,2016,16(26):5196-5200. |
| 鞘氨醇1- 磷酸受体4 研究进展 |
| The Research Progress of Sphingosine-1-phosphate Receptor 4 |
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| DOI： |
| 中文关键词: 鞘氨醇1-磷酸受体4 生物学功能 信号通路 |
| 英文关键词: Sphingosine-1-phosphate Receptor 4 Biological function Signaling pathways |
| 基金项目: |
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| 中文摘要: |
| 鞘氨醇1-磷酸（Sphingosine-1-phosphate，S1P）是一种具有生物学活性的溶血磷脂信号分子，在体内通过G 蛋白偶联受体（G
protein coupled receptor，GPCR）家族鞘氨醇1-磷酸受体（S1P receptors）的5 个亚型（S1P1-5）介导多种生物学功能。S1P4也称内皮
分化基因受体6（Endothelial differentiation gene receptor 6, Edg-6），主要在淋巴组织和造血组织中表达。近年的研究发现，免疫细
胞的迁移分化、骨骼肌前体细胞的迁移、乳腺癌细胞的增殖、TGFβ1 介导的抑制骨骼肌细胞凋亡均与S1P4相关。本文将综述近几
年来关于S1P 介导S1P4的生理病理应答及相关的信号转导机制。 |
| 英文摘要: |
| Sphingosine-1-phosphate (S1P) is a bioactive lipid mediator that regulates a wide range of cellular processes through
its five specific cell-surface G protein-coupled receptors (S1P1-5). S1P4 is known as endothelial differentiation gene receptor 6 (Edg6),
which mainly be expressed in lymphoid tissue and hematopoietic tissue. S1P plays an essential role in the migration and differentiation of
immune cells, in the migration of skeletal muscle precursor cells, and in the proliferation of breast cancer cells and the TGFβ1 induced
inhibition of skeletal muscle cells apoptosis. In this article, we review the physiological and pathological processes in response to S1P
through S1P4 and related signaling mechanisms. |
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