| 李大伟 陈金妮 曹晓琳 张全鹏 罗明英.BDNF与T2DM 及糖尿病周围神经病变的相关性研究[J].现代生物医学进展英文版,2016,16(26):5184-5186. |
| BDNF与T2DM 及糖尿病周围神经病变的相关性研究 |
| Correlation Research of BDNF with T2DMand DPN |
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| DOI： |
| 中文关键词: 脑源性神经营养因子 2 型糖尿病 糖尿病周围神经病变 |
| 英文关键词: BDNF T2DM DPN |
| 基金项目:国家自然科学基金项目（81500377） |
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| 中文摘要: |
| 目的：探讨脑源性神经营养因子（Brain-derived neurotrophic factor，BDNF）与2 型糖尿病（Diabetes mellitus type2，T2DM）及糖
尿病周围神经病变（Diabetic peripheral neuropathy，DPN）的相关性研究。方法：纳入T2DM及DPN 患者各45例，分别对两组患者
血压、血糖、血脂、胰岛素抵抗指数（HOMA-IR）、BDNF等指标进行对比分析。对两组患者BDNF表达水平变化的相关因素进行
Pearson 相关分析以及多因素线性回归分析。结果：DPN 组病程、FBG、HOMA-IR、BDNF分别为（12.16± 5.84）年、（10.24± 3.93）
mmol/L、（3.75± 2.02）、（3.43± 0.94），T2DM 组病程、FBG、HOMA-IR、BDNF 分别为（7.43± 5.29）年、（8.19± 3.35）mmol/L、（2.69±
1.84）、（4.91± 1.67），差异有显著性（P＜0.05）；多因素线性回归分析显示，病程、感觉阈值与BDNF 表达水平相关（P＜0.05）；
Pearson 相关分析显示，BDNF表达水平与HOMA-IR 存在显著负相关（P＜0.05）。结论：DPN患者BDNF水平明显降低，其水平
与感觉阈值、病程、HOMA-IR 呈现负相关。 |
| 英文摘要: |
| Objective:To study the correlation of Brain-derived neurotrophic factor (BDNF) with Diabetes mellitus type 2
(T2DM) and Diabetic peripheral neuropathy (DPN).Methods:45 T2DM patients and 45 DPN patients were selected. The indexes like
blood pressure, blood sugar, blood fat, HOMA-IR and BDNF of two groups were compared. The influence factors for BDNF expression
changes of two groups were analyzed through Pearson correlation and multiple linear regression.Results:The disease course, FBG,
HOMA-IR, BDNF in DPN group was (12.16± 5.84) years, (10.24± 3.93) mmol/L, (3.75± 2.02) and (3.43± 0.94) respectively, but was
(7.43± 5.29) years, (8.19± 3.35) mmol/L, (2.69± 1.84) and (4.91± 1.67) in T2DMgroup; the differences had statistical significance
(P<0.05). The multiple linear regression analysis results indicated that the disease course and threshold of feelings was correlated with the
expression of BDNF (P<0.05). Pearson correlation analysis results indicated that the expression of BDNF was negatively correlated with
HOMA-IR (P<0.05).Conclusion:For DPN patients, the level of BDNF is greatly reduced and negatively correlated with threshold of
feelings, disease course and HOMA-IR. |
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