| 魏秀娟 宗艳杰 宋丽琴 索丹 门俊.血清IL-17 与IL-23 在支气管哮喘患者中的表达水平及其相关性[J].现代生物医学进展英文版,2016,16(26):5138-5140. |
| 血清IL-17 与IL-23 在支气管哮喘患者中的表达水平及其相关性 |
| Association of SerumLevel of Interleukin-17 and Interleukin-23 in Patientswith Bronchial Asthma |
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| DOI： |
| 中文关键词: IL-17 IL-23 支气管哮喘 相关性 |
| 英文关键词: Interleukin-17 Interleukin-23 Bronchial asthma Association |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨IL-17 与IL-23 在支气管哮喘患者血清中的表达水平及其相关性。方法：选择2010 年2 月～2015 年9 月在我院进
行诊治的支气管哮喘患者98例，其中包括56 例为缓解期组，42 例为急性发作期组，对照组为20 例体检健康者，观察三组的血清
IL-17、IL-23 水平及肺功能指标的差异，并分析其相关性。结果：与对照组相比，缓解期组和急性发作期组血清IL-17、IL-23 水平均
明显升高（P<0.05），急性发作期组血清IL-17、IL-23 水平均显著高于缓解期组（P<0.05）；急性发作期组患者的PEF%、FEV1%、
V50%、V25%均明显低于缓解期组，差异有统计学意义（P<0.05）；哮喘患者血清IL-17 水平与IL-23 水平呈正相关( r = 0.685，P =
0.000)，血清IL-17 与FEV1 负相关(r = -0.592，P = 0.000)、与PEF 负相关(r = -0.515，P = 0.000)，IL-23 与FEV1 负相关(r = -0.598，P
= 0.000)，与PEF 负相关(r = -0.532，P = 0.000)。结论：血清IL-17 和IL-23 的高表达可能参与了支气管哮喘的形成，并能影响疾病
的进程，两者表达水平密切相关。 |
| 英文摘要: |
| Objective:To explore the association of the serum level of interleukin-17 and interleukin-23 in patients with bronchial
asthma.Methods:Selected 98 cases of patients with bronchial asthma who were treated in our hospital from January 2010 to September
2015 were divided into catabatic period group (56 cases) and acute-outbreak period group (42 cases) according to the clinical
manifestations, 20 cases of healthy people were selected as control group. The differences of serum IL-17, IL-23 and pulmonary function
in the three groups were compared, and their correlation was analyzed.Results:Compared with the control group, the serum IL-17 and
IL-23 levels were significantly elevated in the catabatic period group and acute-outbreak period group (P<0.05), the serumlevel of IL-17
and IL-23 were significantly higher than those in the catabatic period group (P<0.05). The FEV1%, V50%, V25% and PEF% in the
acute-outbreak period group were significantly lower than those in the catabatic period group (P<0.05). There was positive correlation
between the serum IL -17 and IL -23 levels in asthmatic group ( r = 0.685, P = 0.000), but there were negative correlations between the
serumIL-17 and FEV1(r = -0.592, P = 0.000), IL-17 and PEF(r = -0.515, P = 0.000), IL -23 and FEV1(r = -0.598, P = 0.000), IL -23 and
PEF (r = -0.532,P = 0.000).Conclusion:The high expression of IL-17 and IL-23 may be involved in the formation of bronchial asthma,
and can affect the process of the disease, and their expression is positively correlated. |
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