| 康健 康丽丽 于浩 陶翠 陈黎明.胃溃疡患者血清多肽类激素及胃粘膜中单胺类神经递质的水平及其临床意义[J].现代生物医学进展英文版,2016,16(26):5131-5134. |
| 胃溃疡患者血清多肽类激素及胃粘膜中单胺类神经递质的水平及其临床意义 |
| Levels and Significance of SerumPeptide Hormone and MonoamineNeurotransmitter in Patients with Gastric Ulcer |
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| DOI： |
| 中文关键词: 胃溃疡 单胺类神经递质 多肽激素 |
| 英文关键词: Gastric ulcers Monoamine neurotransmitter Peptide hormones |
| 基金项目:辽宁省科技厅计划项目(2013226012) |
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| 中文摘要: |
| 目的：分析胃溃疡患者血清多肽类激素及单胺类神经递质的水平变化及其临床意义。方法：选取2014 年8 月-2015 年8 月
在我院经胃镜检查确诊为胃溃疡的患者103 例作为研究组，另选取54 例健康志愿者作为对照组。检测两组血清中胃动素
（MTL）、肾上腺髓质素（AM）、胃肠激素胃泌素（Gas）、生长抑素（SS）及降钙素基因相关肽水平（CGRP），以及胃黏膜中血管活性肠
肽（VIP）、5- 羟色胺（5-HT）、去甲肾上腺素（NE）、P物质（SP）水平。结果：胃溃疡患者血清Gas，AM 及MTL明显高于对照组，而
SS及CGRP明显低于对照组，差异具有统计学意义（P＜0.05）。胃溃疡活动期患者血清Gas，AM及MTL明显高于愈合期及瘢痕
期患者，而SS 及CGRP 低于愈合期及瘢痕期患者，差异具有统计学意义（P<0.05）；胃溃疡愈合期患者血清Gas，AM 及MTL高于
瘢痕期患者，而SS及CGRP 低于瘢痕期患者，差异具有统计学意义（P<0.05）。胃溃疡患者胃粘膜内5-HT，SP 及NE 明显低于对
照组，而VIP明显高于对照组，差异具有统计学意义（P＜0.05）。胃溃疡活动期患者胃粘膜5-HT，SP及NE 明显低于愈合期及瘢痕
期患者，而VIP明显高于愈合期及瘢痕期患者，差异具有统计学意义（P＜0.05）；胃溃疡愈合期患者胃粘膜5-HT，SP及NE 明显低
于瘢痕期患者，而VIP 明显高于瘢痕期患者，差异具有统计学意义（P＜0.05）。结论：胃溃疡患者血清多肽类激素及胃黏膜中单胺
类神经递质的水平变化与疾病进展密切相关，对胃溃疡的诊断及疗效评价具有指导意义。 |
| 英文摘要: |
| Objective:To analyze the changes and significance of serum peptide hormone and monoamine neurotransmitter in
patients with gastric ulcer.Methods:103 cases with gastric ulcer who were diagnosed in our hospital from August 2014 to August 2015
were selected as the study group, and another 54 healthy people were selected as the control group. Then the serum levels of peptide
hormones including motilin (MTL), adrenomedullin (AM), gastrointestinal hormone gastrin (Gas), somatostatin (SS) and calcitonin
gene-related peptide (CGRP) and stomach mucosa of vasoactive intestinal peptide (VIP), 5-hydroxytryptamine (5-HT), norepinephrine
(NE) and P substance (SP) were detected and compared between the two groups.Results:The serum levels of Gas, AM and MTL in
patients with gastric ulcer were higher than those of the control group, and the serum levels of SS and CGRP were lower (P<0.05); The
serum levels of Gas, AM and MTL in patients with active gastric ulcer were higher than those of the patients with healing and cicatricial
stage, and the serumlevels of SS and CGRP were lower (P<0.05); The serum levels of Gas, AMand MTL in patients with healing stage
of gastric ulcer were higher than those of the patients with cicatricial stage, and the serum levels of SS and CGRP were lower (P<0.05).
The levels of 5-HT, SP and NE in patients with gastric ulcer were lower than those of the control group, and the levels of VIP were higher
(P<0.05); The levels of 5-HT, SP and NE in patients with active gastric ulcer were lower than those of the patients with healing and
cicatricial stage, and the levels of VIP were higher (P<0.05); The levels of 5-HT, SP and NE in patients with healing stage of gastric ulcer
were lower than those of the patients with cicatricial stage, and the levels of VIP were higher (P<0.05).Conclusion:Changes of serum
peptide hormone and monoamine neurotransmitters in patients with gastric ulcer is closely related to the progress of the disease, which
might be helpful to the diagnosis and treatment of gastric ulcer, as well as to evaluate the clinical efficacy. |
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