| 金巍 徐靖华 刘建光 李跃飞 王宇.舒利迭无创通气对慢性阻塞性肺疾病合并呼吸衰竭患者肺功能及动脉血
气分析的影响[J].现代生物医学进展英文版,2016,16(26):5085-5087. |
| 舒利迭无创通气对慢性阻塞性肺疾病合并呼吸衰竭患者肺功能及动脉血
气分析的影响 |
| Effect of Seretide and Noninvasive Ventilation on the Pulmonary Functionand Arterial Blood Analysis of Patients with Chronic Obstructive PulmonaryDisease Combined with Respiratory Failure |
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| DOI： |
| 中文关键词: 舒利迭 无创通气 慢性阻塞性肺疾病 呼吸衰竭 肺功能 |
| 英文关键词: Seretide Noninvasive ventilation COPD Respiratory failure Pulmonary function |
| 基金项目:辽宁省科技厅计划项目(2013226012) |
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| 中文摘要: |
| 目的：探讨舒利迭联合无创通气对慢性阻塞性肺疾病(COPD)合并呼吸衰竭患者肺功能和动脉血气的影响。方法：选取2013
年5 月-2015 年5 月在我院接受治疗的COPD 合并呼吸衰竭患者92 例，根据治疗方法不同，将患者分为研究组和对照组。对照组
患者给予控制感染、化痰、平喘等常规治疗，研究组在此基础上给予舒利迭无创通气治疗。采用血气分析仪检测两组患者治疗前
后二氧化碳分压（PaCO2）、血氧分压（PaO2）及酸碱度（pH）等动脉血气指标。应用肺功能检测仪检测患者用力肺活量（FVC）、呼气
高峰流量（PEFR）以及1 s用力呼气容积（FEV1）等肺功能指标。结果：治疗前，两组患者PaCO2, PaO2, pH, FVC, PEFR 及FEV1 比
较，差异均无统计学意义（P>0.05）；治疗后，两组患者PaCO2较治疗前明显下降，而PaO2与pH 明显上升，差异具有统计学意义
（P<0.05）；治疗后，研究组PaCO2低于对照组，而PaO2与pH高于对照组，差异具有统计学意义（P<0.05）；治疗后，两组患者FVC，
PEFR 及FEV1 明显上升，且研究组高于对照组，差异均具有统计学意义（P<0.05）。结论：舒利迭联合无创通气对COPD 合并呼吸
衰竭患者肺功能及动脉血气具有明显的改善作用，值得临床推广及应用。 |
| 英文摘要: |
| Objective:To investigate the effect of seretide and noninvasive ventilation on the treatment of patients with chronic
obstructive pulmonary disease (COPD) and respiratory failure.Methods:92 patients with COPD and respiratory failure who were treated
in our hospital from May 2013 to May 2015 were selected and according to the different treatment methods, the patients were divided
into the the research group and the control group. The patients in the control group were treated with the conventional method which
including the control of infection, phlegm and asthma, while the patients in the research group were treated with seretide and noninvasive
ventilation besides of the conventional method. Then the carbon dioxide partial pressure (PaCO2), blood oxygen partial pressure (PaO2),
pH value (pH) and other arterial blood gas indexes were detected by blood gas analyzer. The forced vital capacity (FVC), peak expiratory
flow (PEFR) and the 1s forced expiratory volume (FEV1) of patients were detected by the pulmonary function test.Results:Before
treatment, there was no statistically significant difference about the PaO2, pH, PaCO2, PEFR, FEV1 and FVC in the two groups (P>0.05);
After treatment, the PaCO2 of the two groups significantly decreased, and pH and PaO2 increased, and the difference was statistically
significant (P<0.05); After treatment, the PaCO2 in the research group was lower than that of the control group, and the PaO2 and pH were
higher than those of the control group, and the difference was statistically significant (P<0.05); After treatment, the PEFR, FEV1 and
FVC significantly increased in the two groups, and the research group was higher than that of the control group, and the difference was
statistically significant (P<0.05).Conclusion:Seretide combined with noninvasive ventilation can improve the pulmonary function and
arterial blood gas analysis of patients with COPD and respiratory failure, which is worthy of clinical application. |
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