| 乔久涛 刘艾芸 孙崇毅 陈天新 孙崇然 李明 王冬艳.载脂蛋白Eε4 等位基因与急性脊髓损伤预后的相关性[J].现代生物医学进展英文版,2016,16(26):5072-5076. |
| 载脂蛋白Eε4 等位基因与急性脊髓损伤预后的相关性 |
| Apolipoprotein E Epsilon 4 Allele and Outcomes of Traumatic Spinal CordInjury in a Chinese Han Population |
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| DOI： |
| 中文关键词: 载脂蛋白E 脊髓损伤 基因多态性 |
| 英文关键词: Apolipoprotein E Spinal cord injury Gene polymorphism |
| 基金项目:黑龙江省自然科学基金项目（H201419）；国家自然科学基金项目（80371370） |
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| 中文摘要: |
| 目的：探讨中国汉族人群中载脂蛋白Eε4 等位基因与急性脊髓损伤(ASCI)预后的相关性。方法：采用限制性片段长度多态性
聚合酶链反应（PCR-RFLP）方法，检测2012年5 月-2015 年10 月就诊于哈尔滨医科大学附属第二医院脊柱外科的50 例（男性患
者35 例，女性患者15 例）颈段（C3-C8）脊髓损伤的中国汉族患者载脂蛋白E ε4 等位基因的遗传学状态，并以ASIA 脊髓损伤神
经学分类标准为患者神经功能恢复情况进行评估，分析中国汉族人群中载脂蛋白E着4 等位基因与急性脊髓损伤预后的相关性。
结果：在运动方面，载脂蛋白Eε4 阴性的患者恢复情况显著强于载脂蛋白Eε4 阳性的患者恢复情况（mean 6.1vs 3.7，P=0.04）。而
在针刺觉方面，载脂蛋白E着4 阴性的患者恢复情况显著弱于载脂蛋白Eε4 阳性的患者恢复情况（mean 4.0 vs 6.1，P=0.03）。在轻触
觉方面，载脂蛋白Eε4 阴性和阳性患者的恢复情况没有显著的差异（mean 7.4 vs 5.9，P=0.28）。结论：中国汉族人群中载脂蛋白E
ε4 等位基因与ASCI的预后密切相关：载脂蛋白Eε4 阳性不利于患者运动的恢复，利于患者针刺觉的恢复。 |
| 英文摘要: |
| Objective:To study the relationship between apolipoprotein Eε4 allele and the outcomes after the acute spinal cord
injury (ASCI) in a Chinese Han population.Methods:The genetic status of apolipoprotein E ε4 allele was detected for 50 Chinese Han
patients with cervical spinal cord injury (C3-C8) treated in Second Affiliated Hospital of Harbin Medical University from May 2012 to
October 2015 by restriction fragment length polymorphism polymerase chain reaction (PCR-RFLP ) method. Neurological condition was
assessed using the American Spinal Injury Association (ASIA) International Standards, and the relationship between apolipoprotein Eε
allele and the outcomes after the ASCI in a Chinese Han population was analyzed.Results:Patients with an APOE e4 allele had
significantly less motor recovery than did patients without an APOE e4 allele (mean 3.7 vs. 6.1; P = 0.04), but better sensory-pinprick
recovery (mean 6.1vs. 4.0; P = 0.03). There were no significant differences by APOE e4 allele status in sensory-light touch recovery
(mean 7.4vs. 5.9; P = 0.28).Conclusion:APOE e4 allele is associated with outcomes after ASCI in a Chinese Han population, and An
APOE e4 allele is bad for motor recovery and good for sensory-pinprick recovery. |
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