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目的：探讨衰弱对老年急性冠脉综合征（ACS）患者短期预后的影响。方法：选择2015年8 月1 日至2015 年12 月31 日在我院老年医学中心住院的181 例ACS患者为研究对象。全面评估患者临床特征和合并症情况，采用国际老年营养学会提出的简易虚弱问卷（FRAIL）评估患者的衰弱情况，并根据评估结果将患者分为衰弱组（n=108）和非衰弱组（n=73）。采用门诊随访和电话随访的方式进行3 个月随访，分析衰弱对ACS患者预后的影响。结果：共有181 例患者纳入研究，随访率100%，其中衰弱患者108 例（59.67%）。随访期两组患者再住院、全因死亡和再发急性心肌梗死等随访终点事件发生率比较，差异均有统计学意义（P<0.05）。多因素Logistic 回归分析结果提示衰弱是老年ACS 患者短期再住院、全因死亡和再发急性心肌梗死的独立风险因素（OR=3. 286，4.976，4.346；P=0.032，0.022，0.012）。结论：衰弱是老年ACS患者再住院、全因死亡和再发急性心肌梗死等短期预后的独立风险因素。

英文摘要:

Objective:To explore the impact of weakness on short-term prognosis of elderly patients with acute coronary syndrome (ACS).Methods:Selected 181 cases of patients with ACS who admitted to our hospital in the geriatric medical center from August 2015 to December 2015 as research object. Clinical features and complications in patients were evaluated comprehensively. The debilitating condition of patient was assessed by the international society for elderly nutrition simple weakness questionnaire(FRAIL), According to the evaluation results, the patients were divided into the weak group (n=108) and the non weak group (n=73). 3 months follow-up was produced by outpatient and telephone, and weak influence on the prognosis of patients with ACS was analyzed.Results:A total of 181 patients were included in the study, which the follow-up rate was 100%, and the weakness of these patients were 108 cases (59.7%). Compared the incidence of follow-up terminal event of readmission, all-cause death and recurrence of acute myocardial infarction, the differences were statistically significant (P<0.05). Multiariable Logistic regression analysis results suggested that weakness was the independent risk factor for ACS in elderly patients with short term readmission, all-cause death and recurrence of acute myocardial infarction(OR=3.286, 4.976, 4.346; P=0.032, 0.022, 0.012).Conclusion:Weakness is the independent risk factor of short term prognosis for ACS in elderly patients with readmission, all-cause death and recurrence of acute myocardial infarction.

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