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目的：探讨不同时间高压氧治疗对颅脑损伤患者认知功能障碍的影响。方法：选择了2006 年5 月-2015 年5 月在我院接受高压氧治疗的500 例颅脑损伤手术或非手术患者，根据患者开始采取高压氧治疗时间的不同分为A（入院后7d 内）、B（7-30 d）、C （30 d后）三组，通过相应的治疗比较三组患者认知功能评分、FIM评分及治疗效果。结果：高压氧治疗后，三组患者较治疗前都有了不同程度上的改善，但A 组在定向能力、专注能力、理解能力、复述能力、结构组织能力、记忆能力、计算能力以及自我照顾、转移、行走、交流、社会认知较B组、C 组改善显著（P<0.05），而B组与C组间认知功能各项评分、FIM 评分比较差异无统计学意义（P>0.05）；A 组患者治疗后总有效率为90.63 %，显著优于B组73.89 %的总有效率及C 组70.00 %的总有效率（P<0.05），而B 组与C 组比较差异无统计学意义（P>0.05）。结论：颅脑伤患者尽早的接受高压氧治疗其认知功能改善越明显，治疗效果越好。

英文摘要:

Objective:To investigate the effect of different time of hyperbaric oxygen on the prognosis and cognitive function of traumatic brain injury patients.Methods:500 cases of traumatic brain injury patients accepted hyperbaric oxygen treatment with or without surgery from May 2006 to May 2015 in our hospital were selected and divided into group A (<7 d), B (7-30 d) and C (>30 d) according to the beginning time of hyperbaric oxygen treatment. Then the score of prognosis and cognitive function, FIMscore and effects of three groups were compared.Results:The patients in three groups were all improved. But the directional ability, concentration ability, comprehensive ability, retelling ability, organizational structure ability, memory ability, computing ability and self-care, transferring, walking, exchanging and social cognition in group A were improved significantly compared with group B and C (P<0.05). The cognitive function, FIMscore and effects of B and C group had no statistically significance (P>0.05). The total efficacy of group A was 90.63 %, better than groupB (73.89 %) and groupC (70.00 %) with statistically significance (P<0.05), and there was no statistically significance between group B andC (P>0.05).Conclusion:It is better for traumatic brain injury patients accepted hyperbaric oxygen sooner, which can contribute to improve cognitive function and curative efficacy.

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