| 冯延琴 王理论 边红莉 宗巧梅 刘娟.重组bFGF滴眼液联合杞菊地黄丸对绝经后干眼症女性血清与泪液中
MMP-2及性激素水平的影响[J].现代生物医学进展英文版,2016,16(25):4935-4937. |
| 重组bFGF滴眼液联合杞菊地黄丸对绝经后干眼症女性血清与泪液中
MMP-2及性激素水平的影响 |
| Effect of Recombinant bFGF Combined with Qiju Dihuang on MMP-2 andSex Hormones in Postmenopausal Female Patients with Xerophthalmia |
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| DOI： |
| 中文关键词: 重组bFGF滴眼液 杞菊地黄丸 干眼症 MMP-2 E2 |
| 英文关键词: Recombinant bFGF Qiju Dihuang Dry eye MMP-2 E2 |
| 基金项目:陕西省自然科学基金项目(2006C226) |
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| 中文摘要: |
| 目的：探讨重组bFGF滴眼液联合杞菊地黄丸对绝经后干眼症女性血清与泪液中MMP-2 及性激素水平的影响。方法：收集
我院收治的绝经后干眼症女性患者76 例，随机分为对照组和实验组，每组38 例。对照组患者给予重组牛碱性成纤维细胞生长因
子滴眼液治疗，实验组在对照组基础上给予杞菊地黄丸治疗。观察并比较两组患者治疗前后血清以及泪液中E2、MMP-2 水平。结
果：与治疗前相比，两组患者治疗后血清以及泪液中E2 水平均升高，而MMP-2 水平均下降，差异具有统计学意义(P<0.05)；与对
照组相比，实验组患者治疗后血清以及泪液中E2 水平较高，而MMP-2 水平较低，差异具有统计学意义(P<0.05)。结论：重组bFGF
滴眼液联合杞菊地黄丸能够升高绝经后干眼症女性血清与泪液中E2 水平，降低MMP-2 水平，对临床具有指导意义。 |
| 英文摘要: |
| Objective:To investigate effect of recombinant bFGF combined with Qiju Dihuang on the serum and tear levels of
MMP-2 and sex hormones in postmenopausal female patients with xerophthalmia.Methods:76 postmenopausal female patients with dry
eye who were treated in our hospital were selected and randomly divided into the experiment group and the control group, with 38 cases
in each group. The patients in the control group were treated with recombinant bFGF, while the patients in the experiment group were
treated with recombinant bFGF combined with Qijudihuang. Then the serumand tear levels of E2 and MMP-2 in the two groups were detected
and compared before and after the treatment.Results:Compared with before treatment, the serum and tear levels of E2 in the two
groups increased, while the levels of MMP-2 decreased, and the differences were statistically significant (P<0.05); Compared with the
control group after treatment, the serum and tear levels of E2 and MMP-2 in the experiment group were higher, while the levels of
MMP-2 were lower, and the differences were statistically significant (P<0.05).Conclusion:Recombinant bFGF combined with Qiju Dihuang
can increase the levels of E2 and decrease the levels of MMP-2 in postmenopausal female patients with xerophthalmia. |
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