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目的：分析急性化脓性骨髓炎患者病原菌的分布特点及耐药情况。方法：取急性化脓性骨髓炎患者窦道深部分泌物或病灶组织做细菌培养及药敏试验。结果：80 例患者共培养出病原菌18 种110 株：其中7 例同时培养出3 种细菌，15 例同时培养出2 种细菌，58例培养出1种细菌。110 株细菌中，革兰氏阳性(G+)菌55 株，占50.0%，主要为金黄色葡萄球菌14 株，占25.5%；革兰氏阴性(G-)菌52 株，占47.3%，主要为铜绿假单胞菌13 株，占25.0%。真菌3 株，占2.7%。金黄色葡萄球菌对抗菌药物万古霉素最敏感，耐药率为7.1%，对青霉素耐药率最高，耐药率为92.9%；铜绿假单胞菌对抗菌药物头孢哌酮最敏感，耐药率为7.7%，对亚胺培南的耐药率最高，为92.3%。结论：化脓性骨髓炎的致病菌中革兰氏阳性菌和革兰氏阴性菌的的占比基本持平，大多数病原菌对常用的抗菌药物均具有耐药性。

英文摘要:

Objective:To analyze the distribution and drug resistance of pathogens in patients with acute pyogenic osteomyelitis.Methods:Bacteria culture and drug sensitive test were performed by taking sinus secretionsor tissue in deep focus of infection from patients with pyogenic osteomyelitis.Results:80 patients with pyogenic osteomyelitis were cultured 18 pathogens, including 110 cases: there were 3cases of cultured 7, 15 train 2, 58 patients cultured plant; 110 strains of pathogens including 55 (50.0%) stains of gram-positive bacilli, mainly as Staphylococcus aureus14 (25.5%). 52 (47.3%) stains of gram-negative bacilli, mainly as Pseudomonas aeruginosa 13(25.0%). And 3(2.7%) stains of fungus. Staphylococcus aureus was the most sensitive to vancomycin, the resistance rate was 7.1%, the highest resistance rate to penicillin was 92.9%; Cefoperazone was the most sensitive to Pseudomonas aeruginosa, resistance rate was 7.7%, the highest resistance ratetoimipenem was 92.3%..Conclusion:The proportion of pathogenic gram-positive bacteria and gram-negative bacteria of pyogenic osteomyelitis was substantially equal, the drug-resistant for pathogenic bacteria of most of pyogenic osteomyelitis was found in the common antibacterial agent.

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