| 罗劲松 刘宏 石清照 夏利平 刘苗.环孢霉素A治疗儿童再生障碍性贫血的临床疗效研究[J].现代生物医学进展英文版,2016,16(25):4864-4866. |
| 环孢霉素A治疗儿童再生障碍性贫血的临床疗效研究 |
| Clinical Effect of Cyclosporin A on Children with Aplastic Anemia |
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| DOI： |
| 中文关键词: 环孢霉素A 再生障碍性贫血 睾酮 雌二醇 |
| 英文关键词: Cyclosporin A Aplastic anemia Testosterone Estradiol |
| 基金项目:湖北省自然科学基金项目(2012FFB04418) |
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| 中文摘要: |
| 目的：探讨环孢霉素A 治疗儿童再生障碍性贫血患者的临床疗效。方法：选择在我院就诊或住院治疗的50例儿童再生障碍
性贫血患者，随机分为实验组和对照组，每组25 例。对照组患者给予司坦唑醇治疗，实验组患者在对照组基础上给予环孢素治
疗。治疗结束后，检测并比较两组患者的血清雌二醇、睾酮水平、网织红细胞计数以及临床疗效。结果：与治疗前相比，两组患者治
疗后的血清雌二醇水平均显著下降(P<0.05)，血清睾酮水平以及网织红细胞计数水平均明显升高(P<0.05)；与对照组相比，实验组
患者的血清雌二醇水平较低(P<0.05)，血清睾酮水平以及网织红细胞计数水平较高(P<0.05)。此外，实验组的临床治疗总有效率较
对照组明显升高(P<0.05)。结论：环孢霉素A 可提高儿童AA患者的疗效，可能与其降低血清雌二醇水平，升高血清睾酮水平以及
网织红细胞计数水平有关。 |
| 英文摘要: |
| Objective:To investigate the clinical effect of cyclosporinA in the treatment of children with aplastic anemia.Methods:50 children with aplastic anemia in our hospital were randomly divided into the experimental group and control group, 25 cases in each
group. The control group was treated with stanozolol, patients in the experimental group were given cyclosporine treatment based on the
control group. At the end of treatment, the levels of serum estradiol, testosterone, and the clinical efficacy of both groups were detected
and compared.Results:Compared with before treatment, the serumestradiol levels of both groups were significantly decreased (P<0.05),
the serumtestosterone level and net woven red blood cell count level were significantly increased(P<0.05) after treatment, compared with
the control group, the serum estradiol level of experimental group was lower (P<0.05), the serum testosterone level and network fabric
red cell count were higher(P<0.05). In addition, the total effective rate of experimental group was significantly higher than that of the control
group (P<0.05).Conclusion:Cyclosporin A could improve the efficacy of AA in children, which might be related to the decrease of
serumestradiol level, the increase of serumtestosterone level and red blood cell count. |
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