| 王志海 纪明 荆航 秦琛 王文明.顺铂化疗联合氟尿嘧啶对食管癌患者血清CEA水平的影响[J].现代生物医学进展英文版,2016,16(24):4787-4790. |
| 顺铂化疗联合氟尿嘧啶对食管癌患者血清CEA水平的影响 |
| Effects of Cisplatin Combined with Fluorouracil on the SerumLevels of CEAin Patients with Esophageal Cancer |
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| DOI： |
| 中文关键词: 顺铂 氟尿嘧啶 食管癌 癌胚抗原 |
| 英文关键词: Cisplatin Fluorouracil Esophageal cancer CEA |
| 基金项目:山东省自然科学基金项目(ZR2009CM131) |
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| 中文摘要: |
| 目的：探讨顺铂联合氟尿嘧啶化疗对食管癌患者血清癌胚抗原(CEA)及角蛋白19 片段(Cyfa21-1)浓度的影响及其临床疗效。
方法：选择我院收治的食管癌患者60 例，随机分为实验组和对照组，每组30 例。对照组患者给予氟尿嘧啶，实验组患者在对照组
的基础上联合使用顺铂。比较治疗前后两组患者血清CEA 及Cyfa21-1 浓度的变化，应用KPS 评分表评价两组患者治疗前后的
生活质量，并对比分析两组患者治疗后的临床疗效及不良反应。结果：与治疗前相比，两组患者血清CEA 及Cyfa21-1 浓度均较
低，KPS评分较高(P＜0.05)；与对照组相比，实验组患者血清CEA 及Cyfa21-1浓度较低，KPS 评分较高(P＜0.05)；与对照组相比，
实验组患者临床有效率较高，不良反应发生率较低，差异具有统计学意义(P＜0.05)。结论：顺铂联合氟尿嘧啶能较单用氟尿嘧啶有
效改善食管癌患者的生活质量，提高临床疗效。 |
| 英文摘要: |
| Objective:To investigate the effects of cisplatin combined with fluorouracil on the serum levels of CEA and Cyfa21-1
of patients with esophageal cancer.Methods:60 cases of patients with esophageal cancer from our hospital were collected and randomly
divided into the experimental group and control group, with 30 cases in each group. Patients in the control group were treated by
fluorouracil, while patients in the experimental group were treated by cisplatin combined with fluorouracil. Then the serum CEA and
Cyfra21-1 concentrations of both groups were observed and compared before and after treatment, the quality of life were evaluated by
KPS scores, and the clinical efficacy were analyzed.Results:Compared with before treatment, the serum CEA and Cyfra21-1
concentrations of both groups were decreased, KPS scores were increased (P<0.05). Compared with the control group, the serum CEA
and Cyfra21-1 concentrations of experimental group were lower , KPS score was higher (P<0.05); the clinical efficacy was higher (P<0.
05).Conclusion:Cisplatin combine with fluorouracil had better clinical efficacy in the treatment of patients with esophageal cancer than
fluorouracil alone. |
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