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目的：研究胃癌组织中HER2 基因及P53 蛋白表达情况，分析其对临床诊疗的意义与价值。方法：选取2013 年7 月到2015 年7 月我院确诊的胃癌患者110 例，检测患者胃癌组织中的HER2 蛋白表达与基因扩增，及P53蛋白的表达情况，分析HER2 基因扩增与P53蛋白表达与病理关系间的关系。结果：HER2 基因扩增率为17.3％（19/110），HER2 蛋白表达率为42.7％（47/110）， P53 蛋白表达率为58.2％（64/110），其中HER2蛋白表达3+、2+ 者HER2 基因的扩增比例分别为3/4、6/9 与1+表达者的3/16 比较具有统计学意义（P＜0.05）；HER2 基因扩增和P53 蛋白表达与胃癌淋巴结转移以及浸润程度有关（P＜0.05）；相关性分析显示： HER2 基因扩增与P53 蛋白表达具有正相关关系（P＜0.05）。结论：胃癌组织中HER2基因扩增和P53蛋白协同表达，促进胃癌浸润和淋巴结转移，对胃癌早期诊断具有重要参考价值。

英文摘要:

Objective:To study the expression of HER2 gene and p53 protein in gastric carcinoma tissue, and analyze its significance and value in clinical diagnosis and treatment.Methods:A total of 110 patients with gastric carcinoma, who were diagnosed in Baoji Central Hospital from July 2013 to July 2015, were selected.Then the HER2 protein expression and gene amplification and P53 protein expression were detected, and the relationship among HER2 gene amplification, P53 protein expression and pathological parameters was analyzed.Results:HER2 gene amplification rate was 17.3%(19/110), HER2 protein expression rate was 42.7%(47/110), the P53 protein expression was 58.2%(64/110), and the HER2 gene amplification ratio of HER2 protein expression with 3+,2+ was 3/4 , 6/9 respectively, which had statistical significance compared with 3/16 of expression with 1+ (P<0.05). HER2 gene amplification and P53 protein expression were related with lymph node metastasis and invasion of gastric cancer (P<0.05). Correlation analysis showed that HER2 gene amplification was positively correlated with P53 protein expression (P<0.05).Conclusion:HER2 gene amplification and P53 protein expression cooperate in gastric carcinoma tissue and lead to the invasion and lymph node metastasis,which can be used as the reference for early diagnosis of patients with gastric carcinoma.

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