| 李莉 陈芳 马彩玲 李娜 卢霞.CD44v6和MMP-2 在子宫内膜异位症组织中的表达及相关性[J].现代生物医学进展英文版,2016,16(24):4719-4722. |
| CD44v6和MMP-2 在子宫内膜异位症组织中的表达及相关性 |
| Expression of CD44v6 and MMP-2 in Endometriotic Tissues and TheirsCorrelation |
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| DOI： |
| 中文关键词: CD44v6 MMP-2 子宫内膜异位症 在位内膜 异位内膜 相关性 |
| 英文关键词: CD44 splice variant 6 Matrix metalloproteinase-2 Endometriosis Eutopic endometria Ectopic endometrial Correlation |
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| 中文摘要: |
| 目的：探讨粘附分子CD44拼构变异体6（CD44v6）和基质金属蛋白酶-2（MMP-2）在子宫内膜异位症（EMs）组织中的表达及
相关性。方法：选取40 例异位内膜组织标本、40 例在位内膜组织标本及40 例正常子宫内膜标本，用免疫组织化学方法检测
CD44v6 和MMP-2 的表达，并分析其相关性。结果：CD44v6 在异位内膜组的表达明显高于在位内膜组和对照组，且对照组明显高
于在位内膜组，差异具有统计学意义（P<0.05）；CD44v6 在在位内膜组和对照组中分泌期的表达明显高于同组增生期，差异具有统
计学意义（P<0.05）。MMP-2 在异位内膜组和在位内膜组的表达明显高于对照组，差异具有统计学意义（P<0.01）；MMP-2在各组增
生期和分泌期表达不规律。异位内膜组中，CD44v6 和MMP-2 在Ⅲ-Ⅳ期的表达明显高于Ⅰ-Ⅱ期，差异具有统计学意义（P<0.01）。
Spearman 相关性分析结果显示：EMs 组织中CD44v6 和MMP-2 之间呈现正相关性（r=0.724，P<0.05）；EMs 不同分期组织中
CD44v6 和MMP-2 之间亦呈现正相关性（r=0.623，P<0.05）。结论：CD44v6 和MMP-2 在EMs 异位内膜中高表达，且有正协同作
用，二者可能与EMs的发生发展有关。 |
| 英文摘要: |
| Objective:To investigate the expression and correlation of CD44 splice variant 6 (CD44v6)and matrix
metalloproteinase-2 (MMP-2)in endometriotic tissues and analyzed theirs correlation.Methods:Selected 40 cases of ectopic endometrial
tissue, 40 cases of eutopic endometrial tissue and 40 cases of normal endometrium, detected the expression of CD44v6 and MMP-2 by
Immunohistochemical method, and analyzed their correlation.Results:The expression of CD44v6 in ectopic endometrium group was
significantly higher than that the eutopic endometrium and control groups, the control group was significantly higher than eutopic
endometriumgroup, the differences were statistically significant(P<0.05); The expression of CD44v6 of eutopic endometriumand control
group in progestational stage were significantly higher than that in proliferative stage of the same group, and the differences were
statistically significant (P<0.05). The expression of MMP-2 in ectopic endometrium and eutopic endometrium groups were significantly
higher than that in control group, and the differences were statistically significant (P<0.01); The expression of MMP-2 in the proliferative
stage and progestational stage were not regular in each group. In ectopic endometrium, the expression of CD44v6 and MMP-2 in Ⅲ -Ⅳ
stages were significantly higher than that in I-II stages, and the differences were statistically significant (P<0.01). Spearman correlation
analysis showed that the CD44v6 and MMP-2 in EMS tissues showed positive correlation (r=0.724, P<0.05); the CD44v6 and MMP-2 of
EMS tissues in different stages also revealed positive correlation (r=0.623, P<0.05).Conclusion:The expression of CD44v6 and MMP-2
in ectopic endometriumof EMs are Highly, and has a positive synergistic effect, which may be related to the occurrence and development
of EMs. |
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