| 成玲 张哲林△ 孟根托娅 李志祥 刘晓伟.2 型糖尿病患者血糖波动与心律失常的相关性分析[J].现代生物医学进展英文版,2016,16(24):4672-4675. |
| 2 型糖尿病患者血糖波动与心律失常的相关性分析 |
| Correlation Analysis of Blood Glucose Fluctuation and Arrhythmia in Patients with Type-2 Diabetes |
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| DOI： |
| 中文关键词: 糖尿病 2 型 心律失常 血糖波动 危险因素 |
| 英文关键词: Diabetes Type 2 Cardiac arrhythmias Blood glucose fluctuation Risk factors |
| 基金项目:内蒙古自治区卫生厅和计划生育委员会科研项目（201302057） |
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| 中文摘要: |
| 目的：探讨2 型糖尿病患者血糖波动与心律失常的相关性。方法：收集2 型糖尿病住院患者410 例为研究对象，连续3d 对
患者给予动态血糖监测，平均血糖水平(MBG)及标准差(SD)、日内平均血糖波动幅度(MAGE)以及日间血糖平均绝对差(MODD)；
按照患者住院期间的心电图检查分为心律失常组(n=112 例)和非心律失常组(n=298 例)，分析两组患者血糖波动指标的差异。结
果：410 例住院的2 型糖尿病患者中112 例患者发心律失常，发生率为27.3%，心律失常中以房性早搏为主、其次为窦性心动过
速。心律失常组患者收缩压(SBP)，LDL-C、HbA1c、HOMA-IR 高于非心律失常组(P＜0.05)；而MBG及SD、MAGE 以及MODD亦
高于非心律失常组(P＜0.05)；Logistic 回归分析提示，MAGE(OR=2.478,CI 1.632～5.145，P＜0.05)与心律失常的发生呈现独立相
关。此外糖尿病病程、SBP、HbA1c、HOMA-IR 亦是心律失常的发生的独立危险因素(P＜0.05)。结论：2 型糖尿病患者发生心律失
常的比例较高，且与血糖波动具有一定的相关性，合理控制血糖波动水平对于降低心律失常的发生具有临床意义。 |
| 英文摘要: |
| Objective:To study the correlation analysis of blood glucose fluctuation and arrhythmia in patients with type-2
diabetes.Methods:A total of 410 cases of hospitalized patients in our hospital with type-2 diabetes as the research object. Patients got
dynamic blood sugar monitoring for continuous 3 d, so as to get the average blood glucose levels (MBG) and standard deviation (SD), the
average blood glucose fluctuation (MAGE) in a day and mean absolute difference (MODD) daytime blood sugar. According to the ECG
examination results during hospitalization, patients were divided into arrhythmia group (n=112) and the non-arrhythmia group (n=298).
Then analyze the difference of blood sugar fluctuation index between two groups of patients.Results:Among the 410 cases of
hospitalized patients with type-2 diabetes, 112 cases had arrhythmia, with an incidence of 27.3%. Arrhythmia was given priority to with
atrial premature beats, followed by sinus tachycardia. The systolic blood pressure (SBP), LDL-C, HbA1c, HOMA-IR of patients in
Arrhythmia group was higher than that in the non-arrhythmia group (P<0.05). The MBG and SD, MAGE, and MODD was also higher
than in non-the arrhythmia group (P<0.05). Logistic regression analysis showed that the MAGE (OR = 2.478, CI 2.478 to 1.632, P <0.05)
was independently related with the occurrence of arrhythmia. In addition, SBP, duration of diabetes, HbA1c, HOMA IR were also the
independent risk factors for the occurrence of arrhythmia (P<0.05).Conclusion:Patients with type-2 diabetes had a high incidence of
arrhythmia, and it had a certain relevance with the blood sugar fluctuation. Reasonable control of blood sugar fluctuation levels has
clinical significance in decreasing the occurrence of arrhythmia. |
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