| 左姝 于凯江 王洪亮 郜杨 刘海涛.动态监测血清CRP和PCT水平对脓毒症患者预后判断的临床价值[J].现代生物医学进展英文版,2016,16(24):4664-4667. |
| 动态监测血清CRP和PCT水平对脓毒症患者预后判断的临床价值 |
| The Clinical Value of Dynamic Monitoring of SerumProcalcitonin andC-reactive Protein Levels for the Prognostic Evaluation of Sepsis |
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| DOI： |
| 中文关键词: C 反应蛋白 降钙素原 脓毒症 |
| 英文关键词: C-reactive protein Procalcitonin Septic shock |
| 基金项目:国家自然科学基金项目(81571871) |
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| 中文摘要: |
| 目的：探讨动态监测血清C 反应蛋白(CRP)和降钙素原(PCT)水平对脓毒症患者预后判断的临床应用价值。方法：选择我院
重症监护病房2015 年1 月至2016 年3 月收治的116 例脓毒症患者为研究对象，根据其28 d生存情况分为存活组和死亡组，比
较两组患者入院第1、2、3、5、7 d的血清CRP、PCT 水平的动态变化，入院第1 d白细胞、乳酸、APACHEⅡ评分和SOFA 评分的差
异，并分析血清CRP、PCT水平与APACHEⅡ评分和SOFA 评分的相关性。结果：存活组和死亡组患者第1、2、3 和5 d CRP水平
无统计学差异，但死亡组患者第7 d CRP 水平明显高于存活组，差异具有统计学意义(P＜0.05)；存活组和死亡组患者第1、2和3 d
PCT 水平无统计学差异，但死亡组患者第5、7 d PCT 水平明显高于存活组，差异具有统计学意义(P＜0.05)；入院1 d，死亡组
SOFA 评分、APACHE II评分明显高于存活组，差异有统计学意义(P＜0.05)；入院第7 d，患者CRP 水平与SOFA 评分和APACHE
II 评分呈正相关(R 分别为0.387 和0.396，P 均＜0.01)；入院第7 d，患者PCT 水平与SOFA 评分和APACHE II 评分呈正相关(R
分别为0.472 和0.464，P 均＜0.01)；CRP 为10.0 mg/L时敏感性为79.2 %，特异性为70.8 %。PCT 为2.0 ug/L时敏感性为76.3 %，
特异性为69.4 %。结论：CRP、PCT 可以评价脓毒性患者的严重程度，并且动态观察其变化有助于预测脓毒症患者的预后。 |
| 英文摘要: |
| Objective:To investigate the clinical value of dynamic monitoring of serum procalcitonin(PCT) and c-reactive protein
(CRP) levels for the prognostic evaluation of sepsis.Methods:into the survival group and death group according to the 28 d survival. The
serum CRP and PCT levels on the 1st, 2nd, 3rd, 5th, 7th day after admission were detected and compared. The CRP, PCT, WBC, LAC,
APACHE Ⅱ score and SOFA score on the 1st after admission were compared, and the correlation of serum CRP, PCT levels with
APACHEⅡ score and SOFA score were analyzed.Results:There was no significant difference of CRP on the 1st, 2nd, 3rd, 5th, day after
admission between survival group and death group, but CRP of the death group on the 7th day after admission was higher than that of the
survival group(P<0.05). PCT of the death group on the 5th, 7th day after admission were higher than those of the survival group(P<0.05).
The APACHE II score and SOFA score of death group were significantly higher than those of the survival group(P<0.05). The CRP level
of patients on the 7th day after admission was positively correlated with the APACHE II score and SOFA score (R were 0.396 and 0.387).
The PCT levels of patients on the 7th day after admission was positively correlated with the APACHE II score and SOFA score (R were
0.464 and 0.472). The sensitivity was 79.2 %and specificity was 70.8 %when CRP was 10.0 mg/L. The sensitivity was 76.3 %and the
specificity was 69.4 % when PCT was 2.0 ug/L.Conclusion:Peripheral blood CRP and PCT levels could be used for evaluating the
severity of sepsis, which could predict the severity of illness. |
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