| 杨瑞林 杨永青 李博 第五飞虎 刘强 肖西峰.奥拉西坦联合尼莫地平对自发性蛛网膜下腔出血患者血清IGF-1,
sICAM-1 及sVCAM-1 水平的影响[J].现代生物医学进展英文版,2016,16(24):4657-4660. |
| 奥拉西坦联合尼莫地平对自发性蛛网膜下腔出血患者血清IGF-1,
sICAM-1 及sVCAM-1 水平的影响 |
| Effect of Oxiracetam Combined with Nimodipine on the SerumIGF-1,sICAM-1 and sVCAM-1 Levels of Patients with Spontaneous SubarachnoidHemorrhage* |
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| DOI： |
| 中文关键词: 奥拉西坦 尼莫地平 自发性蛛网膜下腔出血 胰岛素样生长因子-1 可溶性细胞间黏附分子-1 可溶性血管间内皮细胞
黏附分子-1 |
| 英文关键词: Oxiracetam Nimodipine Spontaneous subarachnoid hemorrhage IGF-1 sICAM-1 sVCAM-1 |
| 基金项目:陕西省自然科学基金项目(2007k14-01(4) |
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| 中文摘要: |
| 目的：探讨奥拉西坦联合尼莫地平对自发性蛛网膜下腔出血患者血清胰岛素样生长因子-1 (Insulin like growth factor-1，
IGF-1)、可溶性细胞间黏附分子-1 (Soluble intercellular adhesion molecule-1，sICAM-1) 及可溶性血管间内皮细胞黏附分子-1
(Soluble vascular adhesion molecule-1，sVCAM-1)水平的影响。方法：选取我院收治的自发性蛛网膜下腔出血患者46 例，随机分配
为实验组与对照组，每组23 例。对照组患者给予尼莫地平治疗，实验组在对照组的治疗基础上加用奥拉西坦。比较治疗前后两组
患者血清IGF-1、sICAM-1及sVCAM-1 水平，同时比较治疗结束后两组患者的临床总有效率。结果：与治疗前相比，两组患者治疗
后血清IGF-1 水平升高，sICAM-1 及sVCAM-1 水平降低(P＜0.05)；且与对照组相比，实验组患者血清IGF-1 水平较高，sICAM-1
及sVCAM-1 水平较低，临床总有效率较高(P＜0.05)。结论：奥拉西坦联合尼莫地平能够提高自发性蛛网膜下腔出血患者的临床
疗效，其机制与提高患者血清IGF-1 水平，降低sICAM-1 及sVCAM-1 水平有关。 |
| 英文摘要: |
| Objective:To investigate the effect of oxiracetam combined with nimodipine on the serum IGF-1, sICAM-1 and
sVCAM-1 levels of patients with spontaneous subarachnoid hemorrhage.Methods:46 patients with spontaneous subarachnoid
hemorrhage admitted in our hospital were selected and randomly divided into the control group and the experimental group with 23 cases
in each group. The control group was treated by Nimodipine and the experimental group was treated on the basis of the control group
with Oxiracetam. The serum IGF-1, sICAM-1 and sVCAM-1 levels were detected and compared between two group before and after
treatment. The total clinical efficiency was compared between two groups after treatment.Results:Compared with before treatment, the
serum IGF-1 levels of both groups were higher (P＜0.05), the sICAM-1 and sVCAM-1 levels of both groups were lower (P＜0.05).
Compared with the control group after treatment, the serum IGF-1 level of experimental group was higher (P＜0.05), the sICAM-1 and
sVCAM-1 levels were lower (P＜0.05), the total clinical efficiency was higher (P＜0.05).Conclusion:Oxiracetam combined with
nimodipine could improve the curative effect of patients with spontaneous subarachnoid hemorrhage, the mechanism might be related to
the increase of serumIGF-1 level and decrease of serum sICAM-1 and sVCAM-1 levels. |
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