| 乔晓慧 邢晋放 张佳杰 高峰 杜联芳.实时剪切波弹性定量分析不同睾酮水平大鼠阴茎组织硬度[J].现代生物医学进展英文版,2016,16(24):4640-4642. |
| 实时剪切波弹性定量分析不同睾酮水平大鼠阴茎组织硬度 |
| Quantitative Analysis of Penis Stiffness in Rat with Different Levels ofTestosterone using Shear Wave Elastography |
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| DOI： |
| 中文关键词: 实时剪切波弹性成像 阴茎 硬度 睾酮 |
| 英文关键词: Shear wave elastography Penis Stiffness Testosterone |
| 基金项目:上海申康医院发展中心临床科技创新项目（SHDC22015011）；上海交通大学医学院科技基金项目（14XJ10075）；
上海交通大学附属第一人民医院院级科研项目（0601N16004） |
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| 中文摘要: |
| 目的：利用实时剪切波弹性成像（shear wave elastography, SWE）定量分析不同睾酮水平阴茎组织硬度之间的差异。方法：睾
酮水平不同SD 大鼠两组，低睾酮水平组（1 月龄，睾酮水平1.00~1.50 ng/mL，n=10）和高睾酮水平组（13月龄，睾酮水平2.00~2.50
ng/mL，n=10）。采用放射免疫法测定各组大鼠血清睾酮水平。选用法国SuperSonic Imagine 公司生产的Aixplorer超声诊断仪，启
动SWE 模式对阴茎进行SWE 成像并测量其剪切波硬度（shear wave stiffness, SWS）。分析比较两组大鼠血清睾酮水平之间的差
异及SWS之间的差异。结果：所有大鼠血清睾酮水平及阴茎组织SWS的测量均成功完成。低睾酮水平组大鼠血清睾酮水平为
（1.30± 0.16）ng/mL，高睾酮水平组为（2.29± 0.14）ng/mL，两组大鼠血清睾酮水平存在显著差异（P<0.01）；低睾酮水平组大鼠阴茎
组织SWS为（9.86± 0.72）kPa，高睾酮水平组为（7.80± 1.43）kPa，两组大鼠阴茎组织SWS 存在显著差异（P<0.01）。结论：SWE 可
以检测出睾酮水平不同导致的阴茎组织硬度的差异，提示SWE 可作为一项评价阴茎组织硬度的无创新技术。 |
| 英文摘要: |
| Objective:To quantitatively analyze the differences of penis stiffness with different levels of testosterone using shear
wave elastography (SWE).Methods:Two groups of SD rats with different levels of testosterone: the low testosterone group (1 month,
testosterone 1.00~1.50 ng/mL, n=10) and the high testosterone group (13 month, testosterone 2.00~2.50 ng/mL, n=10). The
radioimmunoassay was used to measure the level of testosterone and the ultrasound device Aixplorer (SuperSonic Imagine,
Aix-en-Provence, France) was used for the SWE imaging and SWS measurement of penis. The differences of the level of testosterone
between the two groups and SWS between the two groups were analyzed.Results:The level of testosterone and SWS of penis were all
successfully measured. The level of testosterone of the two groups was respectively (1.30± 0.16) ng/mL and (2.29± 0.14) ng/mL, there
were significant differences of the level of testosterone between the two groups (P<0.01). The penis SWS of the two groups was
respectively (9.86± 0.72) kPa and (7.80± 1.43) kPa, there were significant differences of penis SWS between the two groups (P<0.01).Conclusion:The differences of penis stiffness with different levels of testosterone can be detected using SWE. Therefore, SWE maybe
serve as a potential noninvasive method of evaluating the penis stiffness. |
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