| 杨信 曾昭华 李静文 蒋品 杜一鹏.利拉鲁肽对ApoE-/-小鼠动脉粥样硬化的影响[J].现代生物医学进展英文版,2016,16(24):4628-4630. |
| 利拉鲁肽对ApoE-/-小鼠动脉粥样硬化的影响 |
| Influence of Liraglutide on Atherosclerosis in ApoE-/- mice |
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| DOI： |
| 中文关键词: 利拉鲁肽 动脉粥样硬化 ApoE 基因缺陷 |
| 英文关键词: Liraglutide Atherosclerosis Apolipoprotein E deficient |
| 基金项目:国家自然科学基金项目（81170280）；2013 年度广东省企业技术研发与升级改造专项基金项目（2013B021800291）；
2014 科技惠民专项基金项目（2014Y2-00186） |
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| 中文摘要: |
| 目的：探讨利拉鲁肽对载脂蛋白E 基因缺陷（ApoE-/-）小鼠动脉粥样硬化（AS）的影响。方法：将24 只无特定病原体（SPF）级
雄性ApoE-/-小鼠（6 周龄）随机分成对照组与实验组，各12 只，分别用高脂饲料、高脂饲料+ 利拉鲁肽饲养，饲养12 周后，比较
两组小鼠AS 斑块面积/管腔面积、内膜厚度/中膜厚度及血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高
密度脂蛋白胆固醇（HDL-C）、一氧化氮（NO）、肿瘤坏死因子琢（TNF-琢）及丙二醛（MDA）水平。结果：实验组AS斑块面积/ 管腔面
积和内膜厚度/中膜厚度均明显低于对照组（P<0.05）。实验组血清TC、TG及LDL-C 水平均明显低于对照组（P<0.05），但两组小
鼠血清HDL-C 水平比较差异无统计学意义（P>0.05）。实验组小鼠血清NO 水平明显高于对照组、血清TNF-α水平明显低于对照
组（P<0.05），但两组小鼠血清MDA水平比较差异无统计学意义（P>0.05）。结论：利拉鲁肽能够改善ApoE-/- 小鼠血脂水平、保护
细胞内皮功能、抑制炎症反应，抗AS 作用显著。 |
| 英文摘要: |
| Objective:To study the influence of Liraglutide on atherosclerosis (AS)in apolipoprotein E deficient (ApoE-/-) mice.Methods:A total of 24 specific pathogen free (SPF)male ApoE-/- mice were divided randomly into control group and experiment group,
with 12 cases in each group, respectively fed with high fat diet and high fat diet+Liraglutide, after 12 weeks feeding,compared the plaque
area/lumen area and intima thickness/intima-media thickness of AS, as well as the levels of serum total cholesterol(TC), triglyceride(TG),
low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), nitric oxide (NO), tumor necrosis factor-α
(TNF-α)and malondialdehyde (MDA).Results:The plaque area/lumen area and intima thickness/intima-media thickness of AS in
experiment group were significantly lower than control group(P<0.05).The levels of serumTC, TG and LDL-C in experiment group were
significantly lower than control group (P<0.05), but there was no significantly differences of the level of serumHDL-C of the two groups
(P>0.05). The level of serum NO in experiment group was significantly higher than control group, on the contrary, the level of serum
TNF-αin experiment group was significantly lower(P<0.05), but there was no significantly differences of the level of serum MDA of the
two groups(P>0.05).Conclusion:Liraglutide can obviously improve the levels of serumlipid, protect cell endothelial function and inhibit
inflammatory reaction of ApoE-/- mice, which effect on anti AS is significant. |
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