| 刘佳丽 陈萌 张冬梅 郭鑫 李亚欢 陈健.Cx43 在调节胃肠运动障碍机制中的研究进展[J].现代生物医学进展英文版,2016,16(23):4577-4581. |
| Cx43 在调节胃肠运动障碍机制中的研究进展 |
| Research Progress of Cx43 in the Regulation of Gastrointestinal Motility Disorders* |
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| DOI： |
| 中文关键词: Cx43 胃肠运动障碍 缝隙连接 |
| 英文关键词: Cx43 Gastrointestinal motility dysfunction Gap junction |
| 基金项目:国家自然科学基金项目(81173192) |
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| 中文摘要: |
| 胃肠运动功能障碍是许多胃肠道疾病及其他疾病的重要临床表现，其发病率高达胃肠道疾病的70 %以上。缝隙连接蛋白
43(connexin 43，Cx43)是细胞间隙连接通讯中最重要的间隙连接蛋白，对胃肠道动力的形成和调节起着关键性作用。中西医治疗
胃肠道疾病临床疗效显著，但其起效的分子机制尚未阐释清楚。本文从Cx43 的细胞间隙连接通讯的角度，对Cx43 在调节胃肠运
动障碍机制中的研究进展作一综述，为进一步探究中西医调节胃肠运动障碍的机制研究奠定基础。 |
| 英文摘要: |
| Gastrointestinal motility dysfunction was an important clinical manifestation of many gastrointestinal diseases and
other diseases, and the incidence rate of gastrointestinal dysfunction in gastrointestinal diseases was above 70 %. Gap junction protein 43
(connexin 43, Cx43) was the most important gap junction protein in cell gap junction communication, which played a key role in the formation
and regulation of gastrointestinal motility. The treatment effect of Traditional Chinese and Western medicine on gastrointestinal
diseases was significant, but the molecular mechanismwas not yet clear. The progress of Cx43 in the regulation of gastrointestinal motility
disorders from the gap junction communication in Cx43 is reviewed in this article, which lays foundation for further research on the
mechanismof the regulation of gastrointestinal motility disorders in Traditional and Modern medicine. |
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